Melatonin and Lisdexamfetamine Interaction
Drug interaction information between Melatonin and Lisdexamfetamine.
Melatonin and Lisdexamfetamine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Melatonin and Lisdexamfetamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lisdexamfetamine does not change how the body's enzymes break down melatonin.
FDA Label Information
From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g., theophylline, duloxetine, melatonin), CYP2D6 (e.g., atomoxetine, desipramine, venlafaxine), CYP2C19 (e.g., omeprazole, lansoprazole, clobazam), and CYP3A4 (e.g., midazolam, pimozide, simvastatin) is necessary when VYVANSE is co-administered [see Clinical Pharmacology (12.3) ] .
Lisdexamfetamine Also Interacts With
- Omeprazole minor
- Simvastatin minor
- Duloxetine minor
- Venlafaxine minor
- Atomoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Melatonin + Lisdexamfetamine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lisdexamfetamine has 14 labeled pairs on file vs Melatonin's 2. In the minor band specifically: Melatonin has 2 (also Tasimelteon); Lisdexamfetamine has 14 (also Omeprazole, Simvastatin, Duloxetine, Venlafaxine).
What mechanism field is on file for Melatonin and Lisdexamfetamine?
Lisdexamfetamine does not change how the body's enzymes break down melatonin.
Lisdexamfetamine's labeled portfolio outnumbers Melatonin
SPL source-record counts only. This page's band is minor · classes on file: Melatonin (Hormone Supplement (Sleep Aid)); Lisdexamfetamine (CNS Stimulant).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Lisdexamfetamine
- Omeprazole
- Simvastatin
- Duloxetine
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.