Melatonin and Tasimelteon Interaction
Drug interaction information between Melatonin and Tasimelteon.
Melatonin and Tasimelteon have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Melatonin and Tasimelteon. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these products target the same sleep receptors in your brain. Using them together could cause excessive sleepiness or change how the prescription medicine works.
FDA Label Information
7.3 Beta-Adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.
Tasimelteon Also Interacts With
- Rifampin moderate
- Fluvoxamine moderate
- Metoprolol minor
- Acebutolol minor
Frequently Asked Questions
What SPL severity band is on file for Melatonin + Tasimelteon?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tasimelteon has 5 labeled pairs on file vs Melatonin's 2. In the minor band specifically: Melatonin has 2 (also Lisdexamfetamine); Tasimelteon has 3 (also Metoprolol, Acebutolol).
What mechanism field is on file for Melatonin and Tasimelteon?
Both of these products target the same sleep receptors in your brain. Using them together could cause excessive sleepiness or change how the prescription medicine works.
Tasimelteon's labeled portfolio outnumbers Melatonin
SPL source-record counts only. This page's band is minor · classes on file: Melatonin (Hormone Supplement (Sleep Aid)); Tasimelteon (Melatonin Receptor Agonist).
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Tasimelteon
- Metoprolol
- Acebutolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.