hydrochlorothiazide vs lisinopril
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Side-by-side comparison of hydrochlorothiazide and lisinopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Monitor blood pressure, renal function, and electrolytes in patients on lisinopril and hydrochlorothiazide tablets and other agents that affect the RAS. Do not coadminister aliskiren with lisinopril and hydrochlorothiazide tablets in patients with diabetes. No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide.
Microzide
Prinivil, Zestril
No summary available.
No summary available.
Information not available.
Information not available.
Information not available.
Information not available.
- • Dizziness
- • Headache
- • Cough
- • Fatigue
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Diarrhea
- Fatigue 10,014
- Nausea 9,709
- Diarrhoea 8,311
- Pain 7,663
- Dyspnoea 7,582
- Fatigue 19,346
- Nausea 17,996
- Diarrhoea 16,771
- Dyspnoea 13,650
- Pain 13,303
No specific warnings noted.
No specific warnings noted.
No pregnancy information available.
No pregnancy information available.
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How to Read This hydrochlorothiazide vs lisinopril Comparison
hydrochlorothiazide is classified in the Thiazide Diuretic drug class, while lisinopril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide has 43,279 submissions while lisinopril has 81,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to these drugs work in different ways to lower blood pressure and do not interfere with how the body breaks each other down.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for hydrochlorothiazide or lisinopril.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.