Insulin Glulisine and Clonidine Interaction
Drug interaction information between Insulin Glulisine and Clonidine.
Insulin Glulisine and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Glulisine and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clonidine can change how insulin affects your blood sugar and can also hide the warning signs of low blood sugar.
FDA Label Information
Drugs that May Increase or Decrease the Blood Glucose Lowering Effect of APIDRA Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs that May Blunt Signs and Symptoms of Hypoglycemia Drugs: Beta-blockers, clonidine, guanethidine, and reserpine. ( 7 ) Antiadrenergic Drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine): Signs and symptoms of hypoglycemia may be reduced or absent.
Insulin Glulisine Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Lithium minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Glulisine + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Insulin Glulisine's 9. In the minor band specifically: Insulin Glulisine has 6 (also Albuterol, Lithium, Epinephrine, Glucagon); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Insulin Glulisine and Clonidine?
Clonidine can change how insulin affects your blood sugar and can also hide the warning signs of low blood sugar.
Clonidine's labeled portfolio outnumbers Insulin Glulisine
SPL source-record counts only. This page's band is minor · classes on file: Insulin Glulisine (Rapid-Acting Insulin); Clonidine (Central Alpha-2 Agonist).
0 major · 3 moderate · 6 minor · 9 total
- Other minor peers for Insulin Glulisine
- Albuterol
- Lithium
- Epinephrine
- Glucagon
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.