Insulin Glulisine and Pramlintide Interaction
Drug interaction information between Insulin Glulisine and Pramlintide.
Insulin Glulisine and Pramlintide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Glulisine and Pramlintide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Pramlintide can increase the risk of low blood sugar when taken with insulin.
FDA Label Information
7 DRUG INTERACTIONS Table 6: Clinically Significant Drug Interactions with APIDRA Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics.
Insulin Glulisine Also Interacts With
- Fluoxetine moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
- Lithium minor
Pramlintide Also Interacts With
- Insulin Aspart moderate
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glargine moderate
- Insulin Human/Insulin Isophane moderate
Frequently Asked Questions
What SPL severity band is on file for Insulin Glulisine + Pramlintide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pramlintide has 13 labeled pairs on file vs Insulin Glulisine's 9. In the moderate band specifically: Insulin Glulisine has 3 (also Fluoxetine, Octreotide); Pramlintide has 9 (also Insulin Aspart, Insulin Degludec, Insulin Detemir, Insulin Glargine).
What mechanism field is on file for Insulin Glulisine and Pramlintide?
Pramlintide can increase the risk of low blood sugar when taken with insulin.
Pramlintide's labeled portfolio outnumbers Insulin Glulisine
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Glulisine (Rapid-Acting Insulin); Pramlintide (Amylin Analog).
0 major · 3 moderate · 6 minor · 9 total
- Other moderate peers for Insulin Glulisine
- Fluoxetine
- Octreotide
0 major · 9 moderate · 4 minor · 13 total
- Other moderate peers for Pramlintide
- Insulin Aspart
- Insulin Degludec
- Insulin Detemir
- Insulin Glargine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.