Insulin Glulisine and Fluoxetine Interaction
Drug interaction information between Insulin Glulisine and Fluoxetine.
Insulin Glulisine and Fluoxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Glulisine and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine can increase the risk of low blood sugar when taken with insulin.
FDA Label Information
7 DRUG INTERACTIONS Table 6: Clinically Significant Drug Interactions with APIDRA Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics.
Insulin Glulisine Also Interacts With
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
- Lithium minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Insulin Glulisine + Fluoxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Insulin Glulisine's 9. In the moderate band specifically: Insulin Glulisine has 3 (also Pramlintide, Octreotide); Fluoxetine has 19 (also Alprazolam, Diazepam, Carbamazepine, Haloperidol).
What mechanism field is on file for Insulin Glulisine and Fluoxetine?
Fluoxetine can increase the risk of low blood sugar when taken with insulin.
Fluoxetine carries more major-labeled pairs than Insulin Glulisine
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Glulisine (Rapid-Acting Insulin); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Insulin Glulisine's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 6 minor · 9 total
- Other moderate peers for Insulin Glulisine
- Pramlintide
- Octreotide
6 major · 19 moderate · 43 minor · 68 total
- Other moderate peers for Fluoxetine
- Alprazolam
- Diazepam
- Carbamazepine
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.