insulin degludec vs liraglutide
Side-by-side comparison of insulin degludec and liraglutide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7.2 Effects of Delayed Gastric Emptying on Oral Medications Liraglutide-containing products, including XULTOPHY 100/3.6, cause a delay of gastric emptying, and thereby have the potential to impact the absorption of concomitantly administered oral medications. In clinical pharmacology trials, liraglutide did not affect the absorption of the tested orally administered medications to any clinically relevant degree [see Clinical Pharmacology ( 12.3 )] . Nonetheless, caution should be exercised when oral medications are concomitantly administered with liraglutide containing products.
Recommendation: Be careful when taking oral medicines with this drug and watch for changes in how well your other medicines work.
Tresiba
Victoza, Saxenda
No summary available.
Liraglutide is a medicine that helps lower blood sugar levels. It is used with diet and exercise to treat type 2 diabetes in adults and children 10 years and older.
Information not available.
Liraglutide helps manage blood sugar levels in people with type 2 diabetes. You should use it along with a healthy diet and regular exercise. It is for adults and children aged 10 and older.
Information not available.
Liraglutide works by mimicking a natural hormone in your body. This hormone helps your pancreas release insulin when your blood sugar is high. It also lowers the amount of sugar your liver makes.
- • Common cold
- • Headache
- • Feeling sick to your stomach
- • Diarrhea
- • Increased lipase (an enzyme)
- • Nausea
- • Diarrhea
- • Vomiting
- • Decreased appetite
- • Upset stomach
- High blood sugar 3,617
- Feeling sick to your stomach 1,381
- Low blood sugar 1,252
- Throwing up 894
- Low blood sugar 886
- Feeling sick to your stomach 7,005
- High blood sugar 3,875
- Throwing up 3,364
- Loose, watery stools 3,263
- Inflammation of the pancreas 2,316
No specific warnings noted.
Liraglutide can cause thyroid tumors in animals. It is not known if it can cause thyroid cancer in humans. You should not take this medicine if you or your family have a history of medullary thyroid carcinoma or if you have Multiple Endocrine Neoplasia syndrome type 2. Tell your doctor if you notice a lump in your neck, have trouble swallowing or breathing, or your voice becomes hoarse.
No pregnancy information available.
Liraglutide may harm your unborn baby. You should only use it during pregnancy if the benefit outweighs the risk. Talk to your doctor if you are pregnant or plan to become pregnant.
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How to Read This insulin degludec vs liraglutide Comparison
insulin degludec is classified in the Ultra-Long-Acting Insulin drug class, while liraglutide sits within the GLP-1 Receptor Agonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, insulin degludec has 8,030 submissions while liraglutide has 19,823. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to liraglutide slows down the movement of food and medicine through your stomach, which can change how your body absorbs pills.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between insulin degludec and liraglutide - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.