Ibuprofen and Warfarin Interaction
Drug interaction information between Ibuprofen and Warfarin.
Ibuprofen and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ibuprofen and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ibuprofen is an anti-inflammatory drug that increases the risk of bleeding when taken with warfarin. Both medications interfere with the body's natural ability to form blood clots.
Ibuprofen Also Interacts With
- Heparin moderate
- Carbamazepine minor
- Digoxin minor
- Fluconazole minor
- Prenatal Multivitamin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Aspirin moderate
- Diclofenac moderate
- Desvenlafaxine moderate
Frequently Asked Questions
What SPL severity band is on file for Ibuprofen + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Ibuprofen's 9. In the moderate band specifically: Ibuprofen has 2 (also Heparin); Warfarin has 28 (also Aspirin, Diclofenac, Desvenlafaxine, Vilazodone).
What mechanism field is on file for Ibuprofen and Warfarin?
Ibuprofen is an anti-inflammatory drug that increases the risk of bleeding when taken with warfarin. Both medications interfere with the body's natural ability to form blood clots.
Warfarin carries more major-labeled pairs than Ibuprofen
SPL source-record counts only. This page's band is moderate · classes on file: Ibuprofen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Ibuprofen's 0. This page itself is in the moderate band, not the major band.
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Aspirin
- Diclofenac
- Desvenlafaxine
- Vilazodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.