Ibuprofen and Fluconazole Interaction
Drug interaction information between Ibuprofen and Fluconazole.
Ibuprofen and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ibuprofen and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluconazole slows down how your body processes this pain reliever, which can lead to much higher levels of the drug in your system.
What To Do
You should be monitored for side effects and your doctor may need to lower your ibuprofen dose.
FDA Label Information
Similarly, the C max and AUC of the pharmacologically active isomer [S-(+)-ibuprofen] were increased by 15% and 82%, respectively, when fluconazole was coadministered with racemic ibuprofen (400 mg) compared to administration of racemic ibuprofen alone.
Ibuprofen Also Interacts With
- Heparin moderate
- Warfarin moderate
- Carbamazepine minor
- Digoxin minor
- Prenatal Multivitamin minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
Can I take Ibuprofen and Fluconazole together?
This is a minor interaction. You should be monitored for side effects and your doctor may need to lower your ibuprofen dose.
How serious is the interaction between Ibuprofen and Fluconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Ibuprofen and Fluconazole interact?
Fluconazole slows down how your body processes this pain reliever, which can lead to much higher levels of the drug in your system.
Understanding the Ibuprofen and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Ibuprofen belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluconazole slows down how your body processes this pain reliever, which can lead to much higher levels of the drug in your system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ibuprofen has 9 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should be monitored for side effects and your doctor may need to lower your ibuprofen dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ibuprofen or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.