Ibuprofen and Fluconazole Interaction
Drug interaction information between Ibuprofen and Fluconazole.
Ibuprofen and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ibuprofen and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole slows down how your body processes this pain reliever, which can lead to much higher levels of the drug in your system.
FDA Label Information
Similarly, the C max and AUC of the pharmacologically active isomer [S-(+)-ibuprofen] were increased by 15% and 82%, respectively, when fluconazole was coadministered with racemic ibuprofen (400 mg) compared to administration of racemic ibuprofen alone.
Ibuprofen Also Interacts With
- Heparin moderate
- Warfarin moderate
- Carbamazepine minor
- Digoxin minor
- Prenatal Multivitamin minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Ibuprofen + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Ibuprofen's 9. In the minor band specifically: Ibuprofen has 7 (also Carbamazepine, Digoxin, Prenatal Multivitamin, Terazosin); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Ibuprofen and Fluconazole?
Fluconazole slows down how your body processes this pain reliever, which can lead to much higher levels of the drug in your system.
Fluconazole carries more major-labeled pairs than Ibuprofen
SPL source-record counts only. This page's band is minor · classes on file: Ibuprofen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Ibuprofen's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Ibuprofen
- Carbamazepine
- Digoxin
- Prenatal Multivitamin
- Terazosin
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.