Ibuprofen and Heparin Interaction
Drug interaction information between Ibuprofen and Heparin.
Ibuprofen and Heparin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ibuprofen and Heparin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Heparin thins the blood, and ibuprofen stops blood cells called platelets from sticking together. Using them together significantly increases your risk of dangerous bleeding.
FDA Label Information
7.2 Platelet Inhibitors Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.
Ibuprofen Also Interacts With
- Warfarin moderate
- Carbamazepine minor
- Digoxin minor
- Fluconazole minor
- Prenatal Multivitamin minor
Heparin Also Interacts With
- Celecoxib moderate
- Hydroxychloroquine moderate
- Indomethacin moderate
- Dipyridamole moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Ibuprofen + Heparin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Heparin has 20 labeled pairs on file vs Ibuprofen's 9. In the moderate band specifically: Ibuprofen has 2 (also Warfarin); Heparin has 10 (also Celecoxib, Hydroxychloroquine, Indomethacin, Dipyridamole).
What mechanism field is on file for Ibuprofen and Heparin?
Heparin thins the blood, and ibuprofen stops blood cells called platelets from sticking together. Using them together significantly increases your risk of dangerous bleeding.
Heparin's labeled portfolio outnumbers Ibuprofen
SPL source-record counts only. This page's band is moderate · classes on file: Ibuprofen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Heparin (Unfractionated Heparin).
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Celecoxib
- Hydroxychloroquine
- Indomethacin
- Dipyridamole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.