fluconazole vs ibuprofen
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Side-by-side comparison of fluconazole and ibuprofen. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Similarly, the C max and AUC of the pharmacologically active isomer [S-(+)-ibuprofen] were increased by 15% and 82%, respectively, when fluconazole was coadministered with racemic ibuprofen (400 mg) compared to administration of racemic ibuprofen alone.
Diflucan
Advil, Motrin
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Ibuprofen is a drug that can reduce pain and fever. It belongs to a class of drugs called NSAIDs.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Ibuprofen can help with minor aches and pains. You can use it for headaches, toothaches, backaches, menstrual cramps, and muscle aches. It can also help with the common cold, minor arthritis pain, and fever.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
Ibuprofen works by reducing hormones that cause pain and swelling in the body. It blocks the production of prostaglandins. Prostaglandins contribute to inflammation and pain signals.
- • Headache
- • Nausea
- • Abdominal pain
- • Nausea
- • Headache
- • Diarrhea
- • Vomiting
- • Dizziness
- Pyrexia 4,121
- Nausea 3,697
- Diarrhoea 3,538
- Fatigue 3,151
- Pain 3,123
- Pain 18,855
- Fatigue 17,866
- Nausea 17,352
- Headache 15,815
- Arthralgia 12,950
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
NSAIDs like ibuprofen may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. NSAIDs also increase the risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
Ask a doctor before using if you are pregnant or breastfeeding. NSAIDs like ibuprofen may cause harm to the fetus.
Also Compare, Nearby Drugs
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How to Read This fluconazole vs ibuprofen Comparison
fluconazole is classified in the Azole Antifungal drug class, while ibuprofen sits within the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluconazole has 17,630 submissions while ibuprofen has 82,838. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluconazole slows down how your body processes this pain reliever, which can lead to much higher levels of the drug in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluconazole or ibuprofen.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.