hydrochlorothiazide vs hydrochlorothiazide/losartan
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Side-by-side comparison of hydrochlorothiazide and hydrochlorothiazide/losartan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Hydrochlorothiazide The administration of a non-steroidal anti-inflammatory agent including a selective COX-2 inhibitor can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Monitor renal function periodically in patients receiving hydrochlorothiazide, losartan, and NSAID therapy. 7.5 The Use of Hydrochlorothiazide with Other Drugs When administered concurrently, the following drugs may interact with thiazide diuretics [see Clinical Pharmacology (12.3) ]: Antidiabetic drugs (oral agents and insulin) — dosage adjustment of the...
Microzide
Hyzaar
No summary available.
Hyzaar is a combination medicine that contains losartan and hydrochlorothiazide. It is used to lower high blood pressure.
Information not available.
Hyzaar is used to treat high blood pressure. Lowering blood pressure reduces your risk of strokes and heart attacks. It is also used to lower the risk of stroke in patients with high blood pressure and an enlarged left ventricle of the heart.
Information not available.
Losartan blocks a substance in your body that tightens blood vessels. This helps blood vessels relax, which lowers blood pressure. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water, which also lowers blood pressure.
- • Dizziness
- • Headache
- • Cough
- • Fatigue
- • Dizziness
- • Upper respiratory infection
- • Cough
- • Back pain
- Fatigue 10,014
- Nausea 9,709
- Diarrhoea 8,311
- Pain 7,663
- Dyspnoea 7,582
- Tiredness 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
No specific warnings noted.
If you are pregnant or plan to become pregnant, stop taking Hyzaar and tell your doctor right away. This medicine can harm or kill your unborn baby.
No pregnancy information available.
Do not take Hyzaar if you are pregnant. It can cause serious harm to your unborn baby, including kidney problems, lung problems, skeletal problems and even death. If you are breastfeeding, talk to your doctor about whether Hyzaar is right for you.
How to Read This hydrochlorothiazide vs hydrochlorothiazide/losartan Comparison
hydrochlorothiazide is classified in the Thiazide Diuretic drug class, while hydrochlorothiazide/losartan sits within the Thiazide Diuretic / ARB Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide has 43,279 submissions while hydrochlorothiazide/losartan has 43,279. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to pain relievers like nsaids can stop blood pressure medicines and water pills from working as well as they should. taking these together can also put extra stress on your kidneys.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for hydrochlorothiazide or hydrochlorothiazide/losartan.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.