cholestyramine vs hydrochlorothiazide/losartan
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Side-by-side comparison of cholestyramine and hydrochlorothiazide/losartan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
( 7.5 ) Cholestyramine and colestipol: Reduced absorption of thiazides. Cholestyramine and colestipol resins — Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively.
Questran
Hyzaar
Cholestyramine is a medicine that helps lower high cholesterol levels in your blood. It works by preventing your body from absorbing cholesterol in the intestines.
Hyzaar is a combination medicine that contains losartan and hydrochlorothiazide. It is used to lower high blood pressure.
This medicine is used with a diet to lower high cholesterol, especially LDL cholesterol (the "bad" cholesterol). It may also help if you have high triglycerides, but it's not the best choice if high triglycerides are your main problem. Lowering cholesterol helps reduce your risk of heart disease.
Hyzaar is used to treat high blood pressure. Lowering blood pressure reduces your risk of strokes and heart attacks. It is also used to lower the risk of stroke in patients with high blood pressure and an enlarged left ventricle of the heart.
Cholestyramine is a resin that binds to bile acids in your intestines. Bile acids help digest fats, including cholesterol. By binding to bile acids, cholestyramine prevents them from being reabsorbed, so your body uses cholesterol to make more bile acids, which lowers cholesterol levels in your blood.
Losartan blocks a substance in your body that tightens blood vessels. This helps blood vessels relax, which lowers blood pressure. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water, which also lowers blood pressure.
- • Constipation
- • Dizziness
- • Upper respiratory infection
- • Cough
- • Back pain
- Diarrhoea 1,631
- Fatigue 877
- Nausea 783
- Arthralgia 621
- Headache 543
- Tiredness 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
Since cholestyramine can affect how your body absorbs other medicines, take other drugs at least 1 hour before or 4 to 6 hours after taking cholestyramine.
If you are pregnant or plan to become pregnant, stop taking Hyzaar and tell your doctor right away. This medicine can harm or kill your unborn baby.
Tell your doctor if you are pregnant or plan to become pregnant. Cholestyramine may affect how you absorb vitamins, so your doctor may recommend supplements. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
Do not take Hyzaar if you are pregnant. It can cause serious harm to your unborn baby, including kidney problems, lung problems, skeletal problems and even death. If you are breastfeeding, talk to your doctor about whether Hyzaar is right for you.
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How to Read This cholestyramine vs hydrochlorothiazide/losartan Comparison
cholestyramine is classified in the Bile Acid Sequestrant drug class, while hydrochlorothiazide/losartan sits within the Thiazide Diuretic / ARB Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cholestyramine has 4,455 submissions while hydrochlorothiazide/losartan has 43,279. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to this medicine acts like a magnet in your stomach and sticks to the water pill, which prevents your body from absorbing it. this can make your blood pressure medicine much less effective.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cholestyramine or hydrochlorothiazide/losartan.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.