aliskiren vs hydrochlorothiazide/lisinopril
Side-by-side comparison of aliskiren and hydrochlorothiazide/lisinopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not co-administer aliskiren with ZESTORETIC in patients with diabetes. Avoid use of aliskiren with ZESTORETIC in patients with renal impairment (GFR < 60 mL/min).
Recommendation: Do not use these drugs together if you have diabetes, and your doctor should check your kidney function and potassium levels closely.
Tekturna
Zestoretic
Tekturna is a medicine used to treat high blood pressure. It helps lower blood pressure, which can reduce the risk of strokes and heart attacks.
Zestoretic is a drug that combines lisinopril and hydrochlorothiazide. It is used to treat high blood pressure.
Tekturna is used to treat high blood pressure in adults and children who weigh at least 110 pounds and are 6 years or older. Lowering your blood pressure helps prevent strokes and heart attacks. It is important to manage high blood pressure with a healthy lifestyle too.
Zestoretic is used to treat high blood pressure. Lowering blood pressure reduces the risk of heart problems and strokes. Controlling high blood pressure should also include managing cholesterol, diabetes, and quitting smoking. Many people need more than one medicine to control their blood pressure.
Tekturna works by blocking a substance in your body called renin. Renin helps to control your blood pressure. By blocking renin, Tekturna helps to lower your blood pressure.
Zestoretic contains two medicines. Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water, which also lowers blood pressure.
- • Diarrhea
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- Weakness 367
- Fall 356
- Feeling sick to your stomach 336
- Shortness of breath 314
- Headache 301
- Feeling tired 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
Tekturna can harm your unborn baby, even causing death. If you become pregnant, stop taking Tekturna right away and tell your doctor.
This drug can cause serious harm or death to an unborn baby. Stop taking Zestoretic as soon as you find out you are pregnant.
Tekturna can cause serious harm or death to an unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor about other blood pressure medicines. Breastfeeding is not recommended while taking Tekturna.
Do not take Zestoretic if you are pregnant. It can harm your unborn baby. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
How to Read This aliskiren vs hydrochlorothiazide/lisinopril Comparison
aliskiren is classified in the Direct Renin Inhibitor drug class, while hydrochlorothiazide/lisinopril sits within the Thiazide Diuretic / ACE Inhibitor Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aliskiren has 1,674 submissions while hydrochlorothiazide/lisinopril has 43,279. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to combining these medications puts too much stress on the system that regulates blood pressure, increasing the risk of fainting and kidney damage.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aliskiren and hydrochlorothiazide/lisinopril - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.