Furosemide and Oxaprozin Interaction
Drug interaction information between Furosemide and Oxaprozin.
Furosemide and Oxaprozin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Furosemide and Oxaprozin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This pain reliever can interfere with how your water pill works to remove salt and fluid from your body. This can make the water pill less effective and might hurt your kidneys.
FDA Label Information
Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Oxaprozin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Furosemide + Oxaprozin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Oxaprozin's 15. In the moderate band specifically: Furosemide has 4 (also Cyclosporine, Lithium, Piroxicam); Oxaprozin has 4 (also Methotrexate, Diflunisal, Warfarin).
What mechanism field is on file for Furosemide and Oxaprozin?
This pain reliever can interfere with how your water pill works to remove salt and fluid from your body. This can make the water pill less effective and might hurt your kidneys.
Furosemide carries more major-labeled pairs than Oxaprozin
SPL source-record counts only. This page's band is moderate · classes on file: Furosemide (Loop Diuretic); Oxaprozin (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Furosemide has 3 major-labeled pairs vs Oxaprozin's 0. This page itself is in the moderate band, not the major band.
3 major · 4 moderate · 29 minor · 36 total
- Other moderate peers for Furosemide
- Cyclosporine
- Lithium
- Piroxicam
0 major · 4 moderate · 11 minor · 15 total
- Other moderate peers for Oxaprozin
- Methotrexate
- Diflunisal
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.