Furosemide and Oxaprozin Interaction
Drug interaction information between Furosemide and Oxaprozin.
Furosemide and Oxaprozin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Furosemide and Oxaprozin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
This pain reliever can interfere with how your water pill works to remove salt and fluid from your body. This can make the water pill less effective and might hurt your kidneys.
What To Do
Your doctor should check your kidney function regularly while you are taking these medicines. Watch for signs of swelling or weight gain from fluid buildup.
FDA Label Information
Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Oxaprozin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
- Aspirin minor
Frequently Asked Questions
Can I take Furosemide and Oxaprozin together?
This is a moderate interaction. Your doctor should check your kidney function regularly while you are taking these medicines. Watch for signs of swelling or weight gain from fluid buildup.
How serious is the interaction between Furosemide and Oxaprozin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Furosemide and Oxaprozin interact?
This pain reliever can interfere with how your water pill works to remove salt and fluid from your body. This can make the water pill less effective and might hurt your kidneys.
Understanding the Furosemide and Oxaprozin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Furosemide belongs to the Loop Diuretic class and Oxaprozin belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: This pain reliever can interfere with how your water pill works to remove salt and fluid from your body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Furosemide has 36 total documented interactions on file in this dataset, and Oxaprozin has 15. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should check your kidney function regularly while you are taking these medicines. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Furosemide or Oxaprozin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.