What the FDA labels say about taking them together
Aspirin and oxaprozin
Oxaprozin's FDA label of December 26, 2024 names aspirin in its contraindications section; aspirin's label does not name oxaprozin itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The oxaprozin label: “Oxaprozin and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of oxaprozin and anticoagulants have an increased risk of serious bleeding compared to the use of either drug …”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the oxaprozin FDA label on DailyMed (effective December 26, 2024, Amneal Pharmaceuticals NY LLC).
What does the aspirin label say about oxaprozin?
Aspirin's label does not name oxaprozin itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Aspirin label, warningsThis product contains an NSAID, which may cause severe stomach bleeding.
Aspirin label, warningsThe chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcohol drinks every day while using this product take more or for a longer time than directed
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the oxaprozin label say about aspirin?
Oxaprozin label, contraindicationsHistory of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Oxaprozin label, drug interactionsDrugs That Interfere with Hemostasis Clinical Impact: Oxaprozin and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of oxaprozin and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. Serotonin release by platelets plays an important role in hemostasis. … Intervention: Monitor patients with concomitant use of oxaprozin with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding [see ].
Oxaprozin label, warnings and precautionsMonitor patients with preexisting asthma (without aspirin sensitivity).
Oxaprozin label (SOLA Pharmaceuticals, LLC, December 3, 2025), contraindicationsKnown hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to oxaprozin or any components of the drug product [see WARNINGS AND PRECAUTIONS (5.7, 5.9)] History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Source: FDA drug label (Oxaprozin, NDA217927), SOLA Pharmaceuticals, LLC, effective December 3, 2025 (SPL set 450f5941-7f10-42fe-e063-6394a90a4803), via openFDA
Source: FDA drug label (Oxaprozin), Amneal Pharmaceuticals NY LLC, effective December 26, 2024 (SPL set d9b0ca6c-4c53-4f6e-918b-02a8c472a194), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Oxaprozin | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.475 per tablet 600 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once