Oxaprozin and Aspirin Interaction
Drug interaction information between Oxaprozin and Aspirin.
Oxaprozin and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxaprozin and Aspirin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Using these drugs together can irritate the stomach lining and increase the risk of bleeding. Taking an NSAID with aspirin does not provide more pain relief than taking the NSAID alone.
What To Do
Watch for signs of bleeding, such as unusual bruising or dark stools. Your doctor may need to monitor you more closely or adjust your medications.
FDA Label Information
Intervention: Monitor patients with concomitant use of COXANTO with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding [ see Warnings and Precautions (5.12) ]. Aspirin Clinical Impact: Controlled clinical studies showed that the concomitant use of NSAIDs and analgesic doses of aspirin does not produce any greater therapeutic effect than the use of NSAIDs alone. In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to use of the...
Oxaprozin Also Interacts With
- Furosemide moderate
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Oxaprozin and Aspirin together?
This is a minor interaction. Watch for signs of bleeding, such as unusual bruising or dark stools. Your doctor may need to monitor you more closely or adjust your medications.
How serious is the interaction between Oxaprozin and Aspirin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Oxaprozin and Aspirin interact?
Using these drugs together can irritate the stomach lining and increase the risk of bleeding. Taking an NSAID with aspirin does not provide more pain relief than taking the NSAID alone.
Understanding the Oxaprozin and Aspirin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Oxaprozin belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Aspirin belongs to the Antiplatelet / NSAID class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Using these drugs together can irritate the stomach lining and increase the risk of bleeding. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Oxaprozin has 15 total documented interactions on file in this dataset, and Aspirin has 47. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Watch for signs of bleeding, such as unusual bruising or dark stools. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Oxaprozin or Aspirin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.