Oxaprozin and Warfarin Interaction
Drug interaction information between Oxaprozin and Warfarin.
Oxaprozin and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Oxaprozin and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Oxaprozin belongs to a group of drugs that can increase the risk of bleeding when paired with warfarin. This happens because both drugs make it much harder for the body to form a clot.
Oxaprozin Also Interacts With
- Furosemide moderate
- Methotrexate moderate
- Diflunisal moderate
- Meloxicam minor
- Aspirin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Oxaprozin + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Oxaprozin's 15. In the moderate band specifically: Oxaprozin has 4 (also Furosemide, Methotrexate, Diflunisal); Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Desvenlafaxine).
What mechanism field is on file for Oxaprozin and Warfarin?
Oxaprozin belongs to a group of drugs that can increase the risk of bleeding when paired with warfarin. This happens because both drugs make it much harder for the body to form a clot.
Warfarin carries more major-labeled pairs than Oxaprozin
SPL source-record counts only. This page's band is moderate · classes on file: Oxaprozin (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Oxaprozin's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other moderate peers for Oxaprozin
- Furosemide
- Methotrexate
- Diflunisal
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.