Fluvoxamine · more major-labeled pairs than Asenapine
SPL labels Fluvoxamine + Asenapine as minor; Fluvoxamine 36 / Asenapine 8 in that band.
Mechanism on file: Fluvoxamine slows down the liver enzyme that breaks down asenapine, which can slightly increase the amount of asenapine in your body.
FDA SPL severity: Minor
Fluvoxamine + Asenapine · SPL mechanism field
Fluvoxamine slows down the liver enzyme that breaks down asenapine, which can slightly increase the amount of asenapine in your body.
Minor band excerpt · Fluvoxamine with Asenapine
Strong CYP1A2 Inhibitors (e.g., Fluvoxamine) Asenapine is metabolized by CYP1A2. Marginal increase of asenapine exposure was observed when asenapine is used with fluvoxamine at 25 mg administered twice daily [see Clinical Pharmacology (12.3)] . However, the tested fluvoxamine dose was suboptimal.
Fluvoxamine · 1 major-labeled pairs (vs Asenapine's 0)
- Alosetron minor
- Alprazolam minor
- Amitriptyline minor
- Aspirin minor
Asenapine · 8 minor + 8 total pairs
- Carbamazepine minor
- Cimetidine minor
- Imipramine minor
- Lithium minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.