asenapine vs fluvoxamine
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Side-by-side comparison of asenapine and fluvoxamine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Strong CYP1A2 Inhibitors (e.g., Fluvoxamine) Asenapine is metabolized by CYP1A2. Marginal increase of asenapine exposure was observed when asenapine is used with fluvoxamine at 25 mg administered twice daily [see Clinical Pharmacology (12.3)] . However, the tested fluvoxamine dose was suboptimal.
Saphris
Luvox
Asenapine (Saphris) is an antipsychotic medicine. It is used to treat bipolar I disorder in adults and children ages 10-17.
Fluvoxamine is a medicine that can help treat obsessive compulsive disorder (OCD). It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Asenapine is used to treat bipolar I disorder. In children ages 10 to 17, it can treat manic or mixed episodes on its own. In adults, it can be used with lithium or valproate to treat these episodes.
Fluvoxamine is used to treat obsessive compulsive disorder (OCD). OCD involves having constant, unwanted thoughts or behaviors that you feel the need to repeat. These thoughts or actions can cause you distress and interfere with your daily life.
Asenapine affects certain chemicals in the brain. These chemicals are called neurotransmitters. By changing the balance of these chemicals, asenapine can help reduce symptoms of bipolar disorder.
Fluvoxamine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluvoxamine can help reduce the symptoms of OCD.
- • Sleepiness
- • Numbness in the mouth
- • Dizziness
- • Changes in taste
- • Nausea
- • Abnormal ejaculation
- • Loss of appetite
- • Problems having an orgasm
- • Weakness
- • Diarrhea
- Drug Interaction 78
- Toxicity To Various Agents 64
- Completed Suicide 61
- Myocarditis 53
- Sedation 39
- Drug Interaction 215
- Nausea 117
- Somnolence 114
- Anxiety 103
- Suicidal Ideation 96
Asenapine may increase the risk of death in elderly patients who have psychosis related to dementia. Asenapine is not approved to treat this condition.
Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. Tell your doctor right away if you have any sudden changes in mood, behavior, thoughts, or feelings, especially if they are new, get worse, or worry you. Watch for suicidal thoughts or actions. Families and caregivers should also be aware of these risks.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who use antipsychotics in the last 3 months of pregnancy may have withdrawal symptoms after birth. There is a pregnancy registry, call 1-866-961-2388.
Tell your doctor if you are pregnant or plan to become pregnant. Fluvoxamine may cause problems for the baby if taken during pregnancy. Fluvoxamine can pass into breast milk and may harm a nursing baby.
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How to Read This asenapine vs fluvoxamine Comparison
asenapine is classified in the Atypical Antipsychotic drug class, while fluvoxamine sits within the Selective Serotonin Reuptake Inhibitor (SSRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, asenapine has 295 submissions while fluvoxamine has 645. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluvoxamine slows down the liver enzyme that breaks down asenapine, which can slightly increase the amount of asenapine in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for asenapine or fluvoxamine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.