etonogestrel vs glecaprevir/pibrentasvir
Side-by-side comparison of etonogestrel and glecaprevir/pibrentasvir. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Concomitant use with some other HCV antiviral medicinal products, such as those containing glecaprevir/pibrentasvir, may increase the risk of ALT elevations [see Warnings and Precautions (5.4)].
Recommendation: Your doctor should monitor your liver health closely with blood tests if you take these together. They may need to adjust your treatment if your liver enzyme levels become too high.
Nexplanon
Mavyret
Etonogestrel and ethinyl estradiol vaginal ring is a birth control ring. It prevents pregnancy by releasing hormones into your body.
Mavyret is a medicine used to treat hepatitis C (HCV) in adults and children 3 years and older. It contains two drugs, glecaprevir and pibrentasvir, that work together to stop the virus from multiplying.
This vaginal ring is used by women of reproductive age to prevent pregnancy. It contains a combination of estrogen and progestin hormones. These hormones stop you from getting pregnant.
Mavyret treats hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6. It can be used in people without cirrhosis or with compensated cirrhosis. Mavyret can also treat genotype 1 in people who have already been treated with certain other HCV medicines.
The ring releases etonogestrel and ethinyl estradiol into your body. These hormones prevent ovulation (the release of an egg from the ovary). They also change the lining of your uterus, making it harder for a fertilized egg to implant.
Mavyret contains glecaprevir and pibrentasvir. Glecaprevir blocks a protein called NS3/4A protease that the virus needs to multiply. Pibrentasvir blocks a protein called NS5A, also needed for the virus to multiply. By blocking these proteins, Mavyret stops the hepatitis C virus from spreading in your body.
- • Vaginal infection
- • Headache (including migraine)
- • Mood changes (like depression or mood swings)
- • Problems with the ring (like discomfort or it coming out)
- • Nausea or vomiting
- • Headache
- • Feeling tired
- • Nausea
- Problem with the product's quality 5,554
- Problem related to the device 5,228
- Device is hard to use 4,562
- Device broke 4,501
- Used the product for the wrong amount of time 3,644
- Feeling tired 2,561
- Headache 2,203
- Nausea 1,125
- Itching 653
- Diarrhea 477
Cigarette smoking increases your risk of serious heart problems from this medicine. This risk is higher if you are over 35 and smoke. If you are over 35 and smoke, you should not use this ring.
Mavyret can cause hepatitis B to become active again if you have had it in the past. This can cause serious liver problems, including liver failure and death. Your doctor will test you for hepatitis B before you start Mavyret. They will also monitor you during and after treatment.
Do not use this ring if you are pregnant. Small amounts of the hormones in this ring can pass into breast milk. This medicine may also reduce milk production.
It is not known if Mavyret will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Mavyret passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking Mavyret.
How to Read This etonogestrel vs glecaprevir/pibrentasvir Comparison
etonogestrel is classified in the Progestin (Implant) drug class, while glecaprevir/pibrentasvir sits within the NS3/4A/NS5A Inhibitor (HCV) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, etonogestrel has 23,489 submissions while glecaprevir/pibrentasvir has 7,019. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to taking these medicines together can cause your liver enzymes to rise, which is a sign of liver stress. this happens because both drugs affect how the liver functions at the same time.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between etonogestrel and glecaprevir/pibrentasvir - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.