darunavir vs dronedarone
Side-by-side comparison of darunavir and dronedarone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
dronedarone ↑ dronedarone Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as cardiac arrhythmias.
Recommendation: This combination is unsafe and should be avoided to prevent serious heart rhythm issues.
Prezista
Multaq
Darunavir is a medicine used to treat HIV. It belongs to a class of drugs called protease inhibitors and must be taken with ritonavir.
Multaq is a medicine that helps lower the risk of needing to stay in the hospital for atrial fibrillation (AFib). It is for people who have a history of AFib and are currently in normal heart rhythm.
Darunavir is used to treat HIV-1 infection in adults and children 3 years and older. It must be taken with ritonavir and other HIV medicines. Darunavir helps to lower the amount of HIV in your body.
Multaq is used to lower the risk of hospitalization if you have atrial fibrillation (AFib). AFib is an irregular heartbeat. This medicine is for people who used to have AFib, but are now in a normal heart rhythm.
Darunavir is a protease inhibitor. It works by blocking an enzyme called protease that HIV needs to make copies of itself. This helps to slow down the spread of HIV in your body.
Multaq is an antiarrhythmic drug. It works by changing the electrical signals in the heart. This helps to keep your heart in a normal rhythm and prevent AFib from returning.
- • Diarrhea
- • Nausea
- • Rash
- • Headache
- • Abdominal pain
- • Diarrhea
- • Nausea
- • Abdominal pain
- • Vomiting
- • Feeling weak or tired
- Baby exposed to drug during pregnancy 1,150
- Interaction between medicines 981
- Pain 889
- Emotional upset 812
- Worry 811
- Irregular heartbeat 1,418
- Shortness of breath 834
- Tiredness 614
- Diarrhea 477
- Nausea 471
Darunavir can cause liver problems. Your doctor should check your liver before you start taking darunavir and during treatment. Tell your doctor right away if you have any signs of liver problems, such as yellowing of the skin or eyes.
Multaq can increase the risk of death, stroke, and heart failure in patients with severe heart failure or permanent AFib. You should not take this medicine if you have severe heart failure that recently required hospitalization or if you have permanent AFib and will not be converted to a normal heart rhythm.
Tell your doctor if you are pregnant or plan to become pregnant. The recommended dose during pregnancy is 600 mg twice daily with ritonavir 100mg and food. Women with HIV should not breastfeed because HIV can be passed to the baby through breast milk.
Multaq can harm an unborn baby. If you are a woman who could become pregnant, use effective birth control while taking Multaq. Do not breastfeed while taking Multaq and for 5 days after your last dose.
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How to Read This darunavir vs dronedarone Comparison
darunavir is classified in the HIV Protease Inhibitor drug class, while dronedarone sits within the Class III Antiarrhythmic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, darunavir has 4,643 submissions while dronedarone has 3,814. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to darunavir raises the level of dronedarone in your blood by slowing its breakdown. this can cause your heart to beat in a dangerous or irregular way.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between darunavir and dronedarone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.