Ezetimibe and Dronedarone Interaction
Drug interaction information between Ezetimibe and Dronedarone.
Ezetimibe and Dronedarone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ezetimibe and Dronedarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dronedarone makes it harder for your body to process the cholesterol medicine, which can lead to severe muscle breakdown.
FDA Label Information
Amiodarone, Dronedarone, Ranolazine, or Calcium Channel Blockers Clinical Impact: The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with ezetimibe and simvastatin. Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed ezetimibe and simvastatin 10 mg/10 mg daily.
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Voriconazole major
- Darunavir major
- Ezetimibe/Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe + Dronedarone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe has 25 labeled pairs on file vs Dronedarone's 22. In the major band specifically: Ezetimibe has 8 (also Amlodipine, Diltiazem, Verapamil, Cyclosporine); Dronedarone has 9 (also Ketoconazole, Clarithromycin, Voriconazole, Darunavir).
What mechanism field is on file for Ezetimibe and Dronedarone?
Dronedarone makes it harder for your body to process the cholesterol medicine, which can lead to severe muscle breakdown.
Dronedarone carries more major-labeled pairs than Ezetimibe
SPL source-record counts only. This page's band is major · classes on file: Ezetimibe (Cholesterol Absorption Inhibitor); Dronedarone (Class III Antiarrhythmic).
Dronedarone has 9 major-labeled pairs vs Ezetimibe's 8.
8 major · 4 moderate · 13 minor · 25 total
- Other major peers for Ezetimibe
- Amlodipine
- Diltiazem
- Verapamil
- Cyclosporine
9 major · 5 moderate · 8 minor · 22 total
- Other major peers for Dronedarone
- Ketoconazole
- Clarithromycin
- Voriconazole
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.