Diflunisal and Meloxicam Interaction
Drug interaction information between Diflunisal and Meloxicam.
Diflunisal and Meloxicam have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Diflunisal and Meloxicam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together increases the chance of serious stomach problems like bleeding or ulcers. Combining them does not provide any extra benefit for your pain or swelling.
FDA Label Information
NSAIDs and Salicylates Clinical Impact: Concomitant use of meloxicam with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [see Warnings and Precautions ( 5.2 )].
Diflunisal Also Interacts With
- Methotrexate moderate
- Cyclosporine moderate
- Celecoxib moderate
- Indomethacin moderate
- Mefenamic Acid moderate
Meloxicam Also Interacts With
- Methotrexate moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Diflunisal + Meloxicam?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's moderate band?
Diflunisal and Meloxicam tie at 17 labeled pairs each. moderate-band counts: Diflunisal 11 alongside Methotrexate, Cyclosporine, Celecoxib, Indomethacin; Meloxicam 2 alongside Methotrexate.
What mechanism field is on file for Diflunisal and Meloxicam?
Using these two drugs together increases the chance of serious stomach problems like bleeding or ulcers. Combining them does not provide any extra benefit for your pain or swelling.
Diflunisal and Meloxicam · moderate-band peers
SPL source-record counts only. This page's band is moderate · classes on file: Diflunisal (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 11 moderate · 6 minor · 17 total
- Other moderate peers for Diflunisal
- Methotrexate
- Cyclosporine
- Celecoxib
- Indomethacin
0 major · 2 moderate · 15 minor · 17 total
- Other moderate peers for Meloxicam
- Methotrexate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.