Diflunisal and Cyclosporine Interaction
Drug interaction information between Diflunisal and Cyclosporine.
Diflunisal and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Diflunisal and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diflunisal may reduce protective substances in the kidneys, which can increase the risk of harmful side effects from cyclosporine. This happens because the kidneys cannot process the drugs as safely.
FDA Label Information
Cyclosporine Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin. NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.
Diflunisal Also Interacts With
- Methotrexate moderate
- Celecoxib moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Diflunisal + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Diflunisal's 17. In the moderate band specifically: Diflunisal has 11 (also Methotrexate, Celecoxib, Indomethacin, Mefenamic Acid); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Diflunisal and Cyclosporine?
Diflunisal may reduce protective substances in the kidneys, which can increase the risk of harmful side effects from cyclosporine. This happens because the kidneys cannot process the drugs as safely.
Cyclosporine carries more major-labeled pairs than Diflunisal
SPL source-record counts only. This page's band is moderate · classes on file: Diflunisal (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Diflunisal's 0. This page itself is in the moderate band, not the major band.
0 major · 11 moderate · 6 minor · 17 total
- Other moderate peers for Diflunisal
- Methotrexate
- Celecoxib
- Indomethacin
- Mefenamic Acid
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.