What the FDA labels say about taking them together
Cyclosporine and diflunisal
Diflunisal's FDA label of August 4, 2026 names cyclosporine in its drug interactions section; cyclosporine's label does not name diflunisal itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The diflunisal label: “Cyclosporine Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal …”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the diflunisal FDA label on DailyMed (effective August 4, 2026, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.).
What does the cyclosporine label say about diflunisal?
Cyclosporine's label does not name diflunisal itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Cyclosporine label, drug interactionsIn addition, concomitant use of NSAIDs with cyclosporine, particularly in the setting of dehydration, may potentiate renal dysfunction.
Cyclosporine label, drug interactionsCyclosporine may reduce the clearance of digoxin, colchicine, prednisolone, HMG-CoA reductase inhibitors (statins), aliskiren, bosentan, dabigatran, repaglinide, NSAIDs, sirolimus, etoposide, and other drugs.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the diflunisal label say about cyclosporine?
Diflunisal label, drug interactionsCyclosporine Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin.
Source: FDA drug label (diflunisal), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective August 4, 2026 (SPL set 666f89b4-fd81-420a-a390-eb1cd4014f61), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Diflunisal | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Pain, Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $1.06 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once