Diflunisal and Celecoxib Interaction
Drug interaction information between Diflunisal and Celecoxib.
Diflunisal and Celecoxib have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Diflunisal and Celecoxib. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs are similar types of pain relievers that can harm the stomach lining. Taking them together increases the risk of stomach problems without helping your pain any more than one drug alone.
FDA Label Information
NSAIDs and Salicylates Clinical Impact: Concomitant use of Celecoxib with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [ see Warnings and Precautions (5.2) ] .
Diflunisal Also Interacts With
- Methotrexate moderate
- Cyclosporine moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Celecoxib Also Interacts With
- Methotrexate moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Diflunisal + Celecoxib?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Celecoxib has 19 labeled pairs on file vs Diflunisal's 17. In the moderate band specifically: Diflunisal has 11 (also Methotrexate, Cyclosporine, Indomethacin, Mefenamic Acid); Celecoxib has 3 (also Methotrexate, Heparin).
What mechanism field is on file for Diflunisal and Celecoxib?
Both drugs are similar types of pain relievers that can harm the stomach lining. Taking them together increases the risk of stomach problems without helping your pain any more than one drug alone.
Celecoxib's labeled portfolio outnumbers Diflunisal
SPL source-record counts only. This page's band is moderate · classes on file: Diflunisal (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Celecoxib (COX-2 Selective NSAID).
0 major · 11 moderate · 6 minor · 17 total
- Other moderate peers for Diflunisal
- Methotrexate
- Cyclosporine
- Indomethacin
- Mefenamic Acid
0 major · 3 moderate · 16 minor · 19 total
- Other moderate peers for Celecoxib
- Methotrexate
- Heparin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.