Delafloxacin and Sucralfate Interaction
Drug interaction information between Delafloxacin and Sucralfate.
Delafloxacin and Sucralfate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Delafloxacin and Sucralfate. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Sucralfate can stick to the antibiotic in your stomach and prevent your body from absorbing it properly.
What To Do
Avoid taking these two medications at the same time to make sure the antibiotic works correctly.
FDA Label Information
7 DRUG INTERACTIONS 7.1 Chelation Agents: Antacids, Sucralfate, Metal Cations, Multivitamins Fluoroquinolones form chelates with alkaline earth and transition metal cations. Oral administration of BAXDELA with antacids containing aluminum or magnesium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, or with formulations containing divalent and trivalent cations such as didanosine buffered tablets for oral suspension or the pediatric powder for oral solution, may substantially interfere with the absorption of BAXDELA, resulting in systemic...
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Warfarin minor
- Ketoconazole minor
- Ciprofloxacin minor
Frequently Asked Questions
Can I take Delafloxacin and Sucralfate together?
This is a minor interaction. Avoid taking these two medications at the same time to make sure the antibiotic works correctly.
How serious is the interaction between Delafloxacin and Sucralfate?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Delafloxacin and Sucralfate interact?
Sucralfate can stick to the antibiotic in your stomach and prevent your body from absorbing it properly.
Understanding the Delafloxacin and Sucralfate Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Delafloxacin belongs to the Fluoroquinolone Antibiotic class and Sucralfate belongs to the Mucosal Protective Agent class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Sucralfate can stick to the antibiotic in your stomach and prevent your body from absorbing it properly. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Delafloxacin has 2 total documented interactions on file in this dataset, and Sucralfate has 20. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid taking these two medications at the same time to make sure the antibiotic works correctly. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Delafloxacin or Sucralfate based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.