Prescription medication · Fluoroquinolone Antibiotic

delafloxacin

Also sold as Baxdela. Baxdela treats acute bacterial skin infections and skin structure infections in adults.

Data updated 2026-05-15

2
InteractionsFew interactions
$72.31
Brand price (NADAC)

delafloxacin (Baxdela) is a prescription Fluoroquinolone Antibiotic. Baxdela treats acute bacterial skin infections and skin structure infections in adults.

Baxdela is an antibiotic that fights bacteria in your body. It is used to treat certain skin infections and pneumonia.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Brand Price

$72.31/unit

Generic Available

No

MELINTA

Pricing data from NADAC (CMS), effective June 19, 2024. Compare all drug costs →

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What it does

Baxdela treats acute bacterial skin infections and skin structure infections in adults.

Common side effects

Nausea, Diarrhea, Headache

Key warnings

Baxdela has a boxed warning.

The sections below are summarized in plain English from delafloxacin's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Baxdela belongs to a class of drugs called fluoroquinolones. It works by stopping bacteria from multiplying. This helps your body fight off the infection.

Serious Warnings

Baxdela has a boxed warning. It can cause serious side effects like tendon problems, nerve damage, and central nervous system problems. It can also make muscle weakness worse if you have myasthenia gravis. Stop taking Baxdela right away if you have any of these side effects.

Known Drug Interactions

minor sucralfate

7 DRUG INTERACTIONS 7.1 Chelation Agents: Antacids, Sucralfate, Metal Cations, Multivitamins Fluoroquinolones form chelates with alkaline earth and transition metal cations. Oral administration of BAXDELA with antacids containing aluminum or magnesium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, or with formulations containing divalent and trivalent cations such as didanosine buffered tablets for oral suspension or the pediatric powder for oral solution, may substantially interfere with the absorption of BAXDELA, resulting in systemic...

Mechanism: Sucralfate can stick to the antibiotic in your stomach and prevent your body from absorbing it properly.

minor zinc sulfate

Oral administration of BAXDELA with antacids containing aluminum or magnesium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, or with formulations containing divalent and trivalent cations such as didanosine buffered tablets for oral suspension or the pediatric powder for oral solution, may substantially interfere with the absorption of BAXDELA, resulting in systemic concentrations considerably lower than desired.

Mechanism: Zinc binds to the antibiotic in your stomach, which stops the body from absorbing it properly. This can make the antibiotic much less effective at fighting your infection.

This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

What should I avoid while taking Baxdela?
Avoid taking antacids, supplements with iron or zinc, or didanosine at the same time as Baxdela tablets. Take Baxdela at least 2 hours before or 6 hours after these products.
Can I take Baxdela if I have kidney problems?
If you have severe kidney problems, your doctor may need to adjust your dose of Baxdela. If your kidney function gets worse while taking Baxdela, your doctor may switch you to the oral form.
What should I do if I experience tendon pain while taking Baxdela?
Stop taking Baxdela immediately and contact your doctor. Avoid exercise and rest the affected area.
Can Baxdela cause nerve problems?
Yes, Baxdela can cause peripheral neuropathy (nerve damage). Tell your doctor right away if you experience numbness, tingling, pain, or weakness in your arms or legs.
Is it safe to drive or operate machinery while taking Baxdela?
Baxdela can cause central nervous system effects like dizziness or confusion. Be careful when driving or operating machinery until you know how Baxdela affects you.
Can Baxdela affect my blood sugar?
Baxdela can cause changes in blood sugar levels. If you have diabetes, monitor your blood sugar carefully while taking Baxdela.
What if I have diarrhea while taking Baxdela?
Diarrhea is a common side effect of Baxdela. However, if you develop severe or persistent diarrhea, it could be a sign of a more serious infection. Contact your doctor.
Can I get a yeast infection while taking Baxdela?
Like other antibiotics, Baxdela can sometimes lead to yeast infections. If you experience symptoms like itching or discharge, talk to your doctor.
What are the symptoms of a hypersensitivity reaction?
Symptoms of a hypersensitivity reaction include skin rash, hives, itching, swelling, or difficulty breathing. Stop taking Baxdela and seek immediate medical attention if you experience any of these symptoms.
Can I take Baxdela if I am allergic to other antibiotics?
You should not take Baxdela if you are allergic to delafloxacin or other fluoroquinolone antibiotics.
What are the common side effects of delafloxacin?
The registry lists Nausea, Diarrhea, Headache, Changes in liver enzyme tests, Vomiting among the most-reported FAERS reaction terms for delafloxacin. These counts are not an individual symptom assessment.
Does delafloxacin interact with other medications?
The registry has 2 documented interaction rows for delafloxacin. Notable source-record pairings include sucralfate, zinc sulfate. These rows are not a complete medication review.
What drug class is delafloxacin?
delafloxacin belongs to the Fluoroquinolone Antibiotic drug class. It requires a prescription (Rx). Baxdela treats acute bacterial skin infections and skin structure infections in adults.
What pregnancy or breastfeeding source fields are listed for delafloxacin?
The FDA label for delafloxacin contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

Related Medications in Fluoroquinolone Antibiotic

Other drugs grouped near delafloxacin - same-class peers and common alternatives.

amikacin

Amikin

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amoxicillin

Amoxil

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amoxicillin/clavulanate

Augmentin

Augmentin is a combination of two medicines, amoxicillin and clavulanate.

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ampicillin/sulbactam

Unasyn

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azithromycin

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Medication Guides

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What the FDA Data Shows for delafloxacin

The FDA label for delafloxacin (sold under brand names such as Baxdela) classifies it as a prescription-only medication in the Fluoroquinolone Antibiotic class. Baxdela treats acute bacterial skin infections and skin structure infections in adults. Official labeling lists 5 commonly reported side effects, including Nausea, Diarrhea, Headache.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. The database also lists 2 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: August 1, 2025

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page