delafloxacin
Brand names: Baxdela
Baxdela is an antibiotic that fights bacteria in your body. It is used to treat certain skin infections and pneumonia.
Drug Pricing (NADAC)
Brand Price
$72.31/unit
Generic Available
No
MELINTA
Pricing data from NADAC (CMS), effective June 19, 2024. Compare all drug costs →
What it does
Baxdela treats acute bacterial skin infections and skin structure infections in adults.
Common side effects
Nausea, Diarrhea, Headache
Key warnings
Baxdela has a boxed warning.
How It Works
Baxdela belongs to a class of drugs called fluoroquinolones. It works by stopping bacteria from multiplying. This helps your body fight off the infection.
How to Take It
You can take Baxdela as an IV infusion or as a tablet. The usual IV dose is 300 mg every 12 hours, infused over 60 minutes. The usual tablet dose is 450 mg every 12 hours. You can take the tablets with or without food, but take them 2 hours before or 6 hours after taking antacids or supplements containing metal cations.
Pregnancy & Breastfeeding
It is not known if Baxdela will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Baxdela passes into breast milk. Talk to your doctor about the best way to feed your baby if you take Baxdela.
Missed Dose
If you miss a dose, take it as soon as you remember if it is within 8 hours of your next dose. If it is less than 8 hours until your next dose, skip the missed dose and continue with your regular schedule.
Storage
Store Baxdela tablets and the injection at room temperature, away from moisture and heat.
Serious Warnings
Baxdela has a boxed warning. It can cause serious side effects like tendon problems, nerve damage, and central nervous system problems. It can also make muscle weakness worse if you have myasthenia gravis. Stop taking Baxdela right away if you have any of these side effects.
Known Drug Interactions
7 DRUG INTERACTIONS 7.1 Chelation Agents: Antacids, Sucralfate, Metal Cations, Multivitamins Fluoroquinolones form chelates with alkaline earth and transition metal cations. Oral administration of BAXDELA with antacids containing aluminum or magnesium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, or with formulations containing divalent and trivalent cations such as didanosine buffered tablets for oral suspension or the pediatric powder for oral solution, may substantially interfere with the absorption of BAXDELA, resulting in systemic con...
Mechanism: Sucralfate can stick to the antibiotic in your stomach and prevent your body from absorbing it properly.
What to do: Avoid taking these two medications at the same time to make sure the antibiotic works correctly.
Oral administration of BAXDELA with antacids containing aluminum or magnesium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, or with formulations containing divalent and trivalent cations such as didanosine buffered tablets for oral suspension or the pediatric powder for oral solution, may substantially interfere with the absorption of BAXDELA, resulting in systemic concentrations considerably lower than desired.
Mechanism: Zinc binds to the antibiotic in your stomach, which stops the body from absorbing it properly. This can make the antibiotic much less effective at fighting your infection.
What to do: Do not take these two medications at the same time. Your doctor or pharmacist can help you create a schedule to space them out safely.
Common Questions
What should I avoid while taking Baxdela?
Can I take Baxdela if I have kidney problems?
What should I do if I experience tendon pain while taking Baxdela?
Can Baxdela cause nerve problems?
Is it safe to drive or operate machinery while taking Baxdela?
Can Baxdela affect my blood sugar?
What if I have diarrhea while taking Baxdela?
Can I get a yeast infection while taking Baxdela?
What are the symptoms of a hypersensitivity reaction?
Can I take Baxdela if I am allergic to other antibiotics?
What are the common side effects of delafloxacin?
Does delafloxacin interact with other medications?
What drug class is delafloxacin?
Is delafloxacin safe during pregnancy?
Related Medications in Fluoroquinolone Antibiotic
Other drugs grouped near delafloxacin — same-class peers and common alternatives.
amikacin
Amikin
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amoxicillin
Amoxil
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.
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amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
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ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
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azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
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What the FDA Data Shows for delafloxacin
The FDA label for delafloxacin (sold under brand names such as Baxdela) classifies it as a prescription-only medication in the Fluoroquinolone Antibiotic class. Baxdela treats acute bacterial skin infections and skin structure infections in adults. Official labeling lists 5 commonly reported side effects, including Nausea, Diarrhea, Headache.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. The database also lists 2 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: August 1, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages