Delafloxacin and Zinc Sulfate Interaction

Drug interaction information between Delafloxacin and Zinc Sulfate.

Delafloxacin and Zinc Sulfate have a documented minor interaction in FDA labeling.

FDA drug labeling documents a minor-severity interaction between Delafloxacin and Zinc Sulfate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Delafloxacin

Fluoroquinolone Antibiotic

Drug B

Zinc Sulfate

Mineral Supplement

How They Interact

Zinc binds to the antibiotic in your stomach, which stops the body from absorbing it properly. This can make the antibiotic much less effective at fighting your infection.

FDA Label Information

Oral administration of BAXDELA with antacids containing aluminum or magnesium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, or with formulations containing divalent and trivalent cations such as didanosine buffered tablets for oral suspension or the pediatric powder for oral solution, may substantially interfere with the absorption of BAXDELA, resulting in systemic concentrations considerably lower than desired.

Delafloxacin Also Interacts With

View all Delafloxacin interactions →

Frequently Asked Questions

What SPL severity band is on file for Delafloxacin + Zinc Sulfate?

Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Zinc Sulfate has 5 labeled pairs on file vs Delafloxacin's 2. In the minor band specifically: Delafloxacin has 2 (also Sucralfate); Zinc Sulfate has 4 (also Levofloxacin, Moxifloxacin, Tetracycline).

What mechanism field is on file for Delafloxacin and Zinc Sulfate?

Zinc binds to the antibiotic in your stomach, which stops the body from absorbing it properly. This can make the antibiotic much less effective at fighting your infection.

Zinc Sulfate's labeled portfolio outnumbers Delafloxacin

SPL source-record counts only. This page's band is minor · classes on file: Delafloxacin (Fluoroquinolone Antibiotic); Zinc Sulfate (Mineral Supplement).

Delafloxacin

0 major · 0 moderate · 2 minor · 2 total

Zinc Sulfate

0 major · 1 moderate · 4 minor · 5 total

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.