Cyclobenzaprine and Clozapine Interaction
Drug interaction information between Cyclobenzaprine and Clozapine.
Cyclobenzaprine and Clozapine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Cyclobenzaprine and Clozapine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs have similar side effects that can slow down your digestive system and cause confusion or dry mouth. Combining them makes these side effects much more likely and can lead to severe constipation or toxicity.
What To Do
Your doctor should monitor you for signs of toxicity or severe stomach issues. They may need to adjust your dose or choose a different medication to avoid these complications.
FDA Label Information
Anticholinergic Drugs Concomitant treatment with clozapine and other drugs with anticholinergic activity (e.g., benztropine, cyclobenzaprine, diphenhydramine) can increase the risk for anticholinergic toxicity and severe gastrointestinal adverse reactions related to hypomotility.
Cyclobenzaprine Also Interacts With
- Tapentadol moderate
- Tranylcypromine moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine minor
- Buprenorphine/Naloxone minor
Clozapine Also Interacts With
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
- Bupropion minor
Frequently Asked Questions
Can I take Cyclobenzaprine and Clozapine together?
This is a moderate interaction. Your doctor should monitor you for signs of toxicity or severe stomach issues. They may need to adjust your dose or choose a different medication to avoid these complications.
How serious is the interaction between Cyclobenzaprine and Clozapine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Cyclobenzaprine and Clozapine interact?
Both drugs have similar side effects that can slow down your digestive system and cause confusion or dry mouth. Combining them makes these side effects much more likely and can lead to severe constipation or toxicity.
Understanding the Cyclobenzaprine and Clozapine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Cyclobenzaprine belongs to the Muscle Relaxant class and Clozapine belongs to the Atypical Antipsychotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs have similar side effects that can slow down your digestive system and cause confusion or dry mouth. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Cyclobenzaprine has 17 total documented interactions on file in this dataset, and Clozapine has 42. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you for signs of toxicity or severe stomach issues. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Cyclobenzaprine or Clozapine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.