Cyclobenzaprine and Tapentadol Interaction
Drug interaction information between Cyclobenzaprine and Tapentadol.
Cyclobenzaprine and Tapentadol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Cyclobenzaprine and Tapentadol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together increases the risk of dangerous slowing of your breathing. They can also cause a serious buildup of a brain chemical called serotonin.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue). Due to the risk of respiratory depression with concomitant use of skeletal muscle relaxants and...
Cyclobenzaprine Also Interacts With
- Clozapine moderate
- Tranylcypromine moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine minor
- Buprenorphine/Naloxone minor
Tapentadol Also Interacts With
- Metaxalone moderate
- Tranylcypromine moderate
- Gabapentin minor
- Trazodone minor
- Tramadol minor
Frequently Asked Questions
What SPL severity band is on file for Cyclobenzaprine + Tapentadol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclobenzaprine has 17 labeled pairs on file vs Tapentadol's 16. In the moderate band specifically: Cyclobenzaprine has 3 (also Clozapine, Tranylcypromine); Tapentadol has 3 (also Metaxalone, Tranylcypromine).
What mechanism field is on file for Cyclobenzaprine and Tapentadol?
Taking these drugs together increases the risk of dangerous slowing of your breathing. They can also cause a serious buildup of a brain chemical called serotonin.
Cyclobenzaprine's labeled portfolio outnumbers Tapentadol
SPL source-record counts only. This page's band is moderate · classes on file: Cyclobenzaprine (Muscle Relaxant); Tapentadol (Opioid / Norepinephrine Reuptake Inhibitor).
0 major · 3 moderate · 14 minor · 17 total
- Other moderate peers for Cyclobenzaprine
- Clozapine
- Tranylcypromine
0 major · 3 moderate · 13 minor · 16 total
- Other moderate peers for Tapentadol
- Metaxalone
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.