Acetaminophen/Oxycodone · larger labeled portfolio than Cyclobenzaprine
SPL labels Cyclobenzaprine + Acetaminophen/Oxycodone as minor; Cyclobenzaprine 14 / Acetaminophen/Oxycodone 21 in that band.
Mechanism on file: Both drugs increase serotonin levels in the brain, which can cause a serious reaction called serotonin syndrome.
FDA SPL severity: Minor
Cyclobenzaprine + Acetaminophen/Oxycodone · SPL mechanism field
Both drugs increase serotonin levels in the brain, which can cause a serious reaction called serotonin syndrome.
Minor band excerpt · Cyclobenzaprine with Acetaminophen/Oxycodone
Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tryptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), and monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and...
Cyclobenzaprine · 14 minor + 17 total pairs
- Buprenorphine minor
- Buprenorphine (Pain) minor
- Buprenorphine/Naloxone minor
- Codeine minor
Acetaminophen/Oxycodone · 23 SPL pairs (broader portfolio than Cyclobenzaprine)
- Acetaminophen minor
- Butorphanol minor
- Carbamazepine minor
- Erythromycin minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.