clozapine vs cyclobenzaprine
Side-by-side comparison of clozapine and cyclobenzaprine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Anticholinergic Drugs Concomitant treatment with clozapine and other drugs with anticholinergic activity (e.g., benztropine, cyclobenzaprine, diphenhydramine) can increase the risk for anticholinergic toxicity and severe gastrointestinal adverse reactions related to hypomotility.
Recommendation: Your doctor should monitor you for signs of toxicity or severe stomach issues. They may need to adjust your dose or choose a different medication to avoid these complications.
Clozaril
Flexeril, Amrix
Versacloz is a medicine used to treat severe schizophrenia when other medicines have not worked. It can also help lower the risk of suicidal behavior in people with schizophrenia or schizoaffective disorder.
Cyclobenzaprine is a muscle relaxant. It helps relieve muscle spasms and pain.
Versacloz is used to treat schizophrenia in people who haven't responded well to other antipsychotic medicines. Schizophrenia is a mental illness that can cause hallucinations, delusions, and disorganized thinking. Versacloz can also help lower the risk of repeated suicidal behavior in people with schizophrenia or schizoaffective disorder who are at high risk.
This medicine treats muscle spasms caused by painful conditions. It is meant to be used with rest and physical therapy. It should only be used for a short time, usually 2 to 3 weeks.
Versacloz works by affecting certain chemicals in the brain. These chemicals, like dopamine and serotonin, are involved in mood, behavior, and thinking. By changing the levels of these chemicals, Versacloz can help reduce symptoms of schizophrenia and lower the risk of suicidal behavior.
Cyclobenzaprine works in the brain and spinal cord to relax your muscles. It reduces muscle spasms, which helps to relieve pain and improve movement. It does not directly work on the muscles themselves.
- • Feeling sleepy
- • Dizziness
- • Headache
- • Shaking
- • Fast heart rate
- • Drowsiness
- • Dry mouth
- • Fatigue
- • Headache
- Low white blood cell count 18,655
- Needing to stay in the hospital 12,101
- Death 11,398
- A mental disorder that affects how a person thinks, feels, and behaves 4,547
- High white blood cell count 4,446
- Pain 4,873
- Tiredness 3,808
- Feeling sick to your stomach 3,304
- Headache 3,292
- Long-term kidney problems 2,749
Versacloz can cause several serious side effects: * **Severe Neutropenia:** This means a dangerously low white blood cell count, which increases your risk of infection. You will need regular blood tests to check your white blood cell count. * **Orthostatic Hypotension, Bradycardia, and Syncope:** This means low blood pressure when standing up, slow heart rate, and fainting. These are most likely when you first start taking Versacloz or when the dose is increased. * **Seizures:** Versacloz can increase your risk of seizures, especially at higher doses. * **Myocarditis, Pericarditis, and Cardiomyopathy:** These are serious heart problems that can be fatal. Tell your doctor right away if you have chest pain, shortness of breath, or other heart-related symptoms. * **Increased Mortality in Elderly Patients with Dementia-Related Psychosis:** Elderly patients with dementia who take antipsychotic medicines like Versacloz have an increased risk of death.
You should not take this medicine if you are allergic to any of its ingredients. You should not take this medicine if you are taking a monoamine oxidase (MAO) inhibitor or have taken one in the past 14 days. Taking cyclobenzaprine with an MAO inhibitor can cause serious problems, including seizures and death. Also, do not take it if you have heart problems or an overactive thyroid.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take Versacloz in the third trimester may have withdrawal symptoms or other problems after birth. There is a pregnancy registry for women who take atypical antipsychotics like Versacloz.
It is not known if cyclobenzaprine can harm an unborn baby. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Also Compare, Nearby Drugs
Compare clozapine with
Compare cyclobenzaprine with
How to Read This clozapine vs cyclobenzaprine Comparison
clozapine is classified in the Atypical Antipsychotic drug class, while cyclobenzaprine sits within the Muscle Relaxant class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clozapine has 51,147 submissions while cyclobenzaprine has 18,026. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to both drugs have similar side effects that can slow down your digestive system and cause confusion or dry mouth. combining them makes these side effects much more likely and can lead to severe constipation or toxicity.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between clozapine and cyclobenzaprine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.