colchicine vs darunavir
Side-by-side comparison of colchicine and darunavir. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Anti-gout: colchicine ↑ colchicine Co-administration is contraindicated in patients with renal and/or hepatic impairment due to potential for serious and/or life-threatening reactions. For patients without renal or hepatic impairment: Treatment of gout-flares – co-administration of colchicine in patients on darunavir/ritonavir: 0.6 mg (1 tablet) × 1 dose, followed by 0.3 mg (half tablet) 1 hour later. Prophylaxis of gout-flares – co-administration of colchicine in patients on darunavir/ritonavir: If the original regimen was 0.6 mg twice a day, the regimen should be adjusted to 0.3 mg once...
Recommendation: People with liver or kidney disease must avoid this combination. Others will need their doctor to carefully lower their colchicine dose.
Colcrys, Mitigare
Prezista
Colchicine is a medicine used to prevent or treat gout flares and Familial Mediterranean Fever (FMF). It works by reducing inflammation and pain.
Darunavir is a medicine used to treat HIV. It belongs to a class of drugs called protease inhibitors and must be taken with ritonavir.
Colchicine is used to prevent and treat gout flares in adults. Gout flares cause sudden, severe pain, redness, and swelling in your joints. Colchicine is also used to treat Familial Mediterranean Fever (FMF) in adults and children ages 4 and older. FMF causes recurring fevers and pain in the abdomen, chest, or joints.
Darunavir is used to treat HIV-1 infection in adults and children 3 years and older. It must be taken with ritonavir and other HIV medicines. Darunavir helps to lower the amount of HIV in your body.
Colchicine reduces inflammation in the body. It does this by blocking certain processes that cause swelling and pain. This helps to relieve gout flares and manage FMF symptoms.
Darunavir is a protease inhibitor. It works by blocking an enzyme called protease that HIV needs to make copies of itself. This helps to slow down the spread of HIV in your body.
- • Diarrhea
- • Abdominal pain
- • Nausea
- • Vomiting
- • Diarrhea
- • Nausea
- • Rash
- • Headache
- • Abdominal pain
- Diarrhea 2,661
- Feeling sick to your stomach 1,940
- Feeling very tired 1,745
- Difficulty breathing 1,466
- Sudden damage to the kidneys 1,436
- Baby exposed to drug during pregnancy 1,150
- Interaction between medicines 981
- Pain 889
- Emotional upset 812
- Worry 811
Taking too much colchicine can be fatal in both adults and children. Keep this medicine out of the reach of children. Colchicine can also cause serious blood problems and muscle weakness. Certain medicines can interact with colchicine and cause life-threatening problems. Talk to your doctor about all the medicines you take.
Darunavir can cause liver problems. Your doctor should check your liver before you start taking darunavir and during treatment. Tell your doctor right away if you have any signs of liver problems, such as yellowing of the skin or eyes.
Tell your doctor if you are pregnant or plan to become pregnant. Colchicine may harm your unborn baby. It is not known if colchicine passes into breast milk. Talk to your doctor about the risks and benefits of taking colchicine while breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. The recommended dose during pregnancy is 600 mg twice daily with ritonavir 100mg and food. Women with HIV should not breastfeed because HIV can be passed to the baby through breast milk.
How to Read This colchicine vs darunavir Comparison
colchicine is classified in the Anti-Gout Agent drug class, while darunavir sits within the HIV Protease Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, colchicine has 9,248 submissions while darunavir has 4,643. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to darunavir makes it harder for your body to get rid of colchicine, which can cause the medicine to reach toxic levels. this is especially dangerous for people with liver or kidney problems.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between colchicine and darunavir - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.