Codeine and Oxycodone Interaction
Drug interaction information between Codeine and Oxycodone.
Codeine and Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Codeine and Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs are strong pain relievers that slow down your breathing and brain activity. Taking them together can make these side effects much stronger and more dangerous.
FDA Label Information
If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids (such as oxycodone, hydrocodone, oxymorphone, hydrocodone, or buprenorphine) to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression.
Codeine Also Interacts With
- Bupropion minor
- Fluoxetine minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Frequently Asked Questions
What SPL severity band is on file for Codeine + Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Oxycodone has 28 labeled pairs on file vs Codeine's 27. In the minor band specifically: Codeine has 27 (also Bupropion, Fluoxetine, Trazodone, Tramadol); Oxycodone has 22 (also Trazodone, Tramadol, Cyclobenzaprine, Pregabalin).
What mechanism field is on file for Codeine and Oxycodone?
Both drugs are strong pain relievers that slow down your breathing and brain activity. Taking them together can make these side effects much stronger and more dangerous.
Oxycodone's labeled portfolio outnumbers Codeine
SPL source-record counts only. This page's band is minor · classes on file: Codeine (Opioid Analgesic); Oxycodone (Opioid Analgesic).
0 major · 0 moderate · 27 minor · 27 total
- Other minor peers for Codeine
- Bupropion
- Fluoxetine
- Trazodone
- Tramadol
0 major · 6 moderate · 22 minor · 28 total
- Other minor peers for Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Pregabalin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.