Cimetidine and Empagliflozin/Linagliptin Interaction
Drug interaction information between Cimetidine and Empagliflozin/Linagliptin.
Cimetidine and Empagliflozin/Linagliptin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Cimetidine and Empagliflozin/Linagliptin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine interferes with how the kidneys get rid of metformin, which can cause the drug to build up in your body. High levels of metformin increase the risk of a life-threatening condition called lactic acidosis.
FDA Label Information
Drugs that Reduce Metformin Clearance Clinical Impact Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] .
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Empagliflozin/Linagliptin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Empagliflozin minor
- Topiramate minor
Frequently Asked Questions
What SPL severity band is on file for Cimetidine + Empagliflozin/Linagliptin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Empagliflozin/Linagliptin's 11. In the moderate band specifically: Cimetidine has 10 (also Empagliflozin, Ertugliflozin, Hydroxychloroquine, Linagliptin); Empagliflozin/Linagliptin has 4 (also Metformin, Dolutegravir, Ranolazine).
What mechanism field is on file for Cimetidine and Empagliflozin/Linagliptin?
Cimetidine interferes with how the kidneys get rid of metformin, which can cause the drug to build up in your body. High levels of metformin increase the risk of a life-threatening condition called lactic acidosis.
Cimetidine carries more major-labeled pairs than Empagliflozin/Linagliptin
SPL source-record counts only. This page's band is moderate · classes on file: Cimetidine (H2 Receptor Antagonist); Empagliflozin/Linagliptin (SGLT2 / DPP-4 Combination).
Cimetidine has 4 major-labeled pairs vs Empagliflozin/Linagliptin's 0. This page itself is in the moderate band, not the major band.
4 major · 10 moderate · 63 minor · 77 total
- Other moderate peers for Cimetidine
- Empagliflozin
- Ertugliflozin
- Hydroxychloroquine
- Linagliptin
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Empagliflozin/Linagliptin
- Metformin
- Dolutegravir
- Ranolazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.