Carisoprodol and Rifampin Interaction
Drug interaction information between Carisoprodol and Rifampin.
Carisoprodol and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carisoprodol and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the liver enzymes that process carisoprodol. This can lower the amount of medicine in your system and make it less effective.
FDA Label Information
Co-administration of CYP2C19 inducers, such as rifampin or St.
Carisoprodol Also Interacts With
- Omeprazole minor
- Aspirin minor
- Fluvoxamine minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Carisoprodol + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Carisoprodol's 4. In the minor band specifically: Carisoprodol has 4 (also Omeprazole, Aspirin, Fluvoxamine); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Carisoprodol and Rifampin?
Rifampin speeds up the liver enzymes that process carisoprodol. This can lower the amount of medicine in your system and make it less effective.
Rifampin carries more major-labeled pairs than Carisoprodol
SPL source-record counts only. This page's band is minor · classes on file: Carisoprodol (Centrally Acting Muscle Relaxant); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Carisoprodol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Carisoprodol
- Omeprazole
- Aspirin
- Fluvoxamine
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.