What the FDA labels say about taking them together
Carisoprodol and omeprazole
Carisoprodol's FDA label of July 15, 2025 names omeprazole in its drug interactions section; the omeprazole labels PlainMeds reads (2) do not name carisoprodol. The carisoprodol label: “Co-administration of CYP2C19 inhibitors, such as omeprazole or fluvoxamine, with carisoprodol could result in increased exposure of carisoprodol and decreased exposure of meprobamate.”
Check it at the source: the carisoprodol FDA label on DailyMed (effective July 15, 2025, Mylan Pharmaceuticals Inc.); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the carisoprodol label say about omeprazole?
Carisoprodol label, drug interactionsCo-administration of CYP2C19 inhibitors, such as omeprazole or fluvoxamine, with carisoprodol could result in increased exposure of carisoprodol and decreased exposure of meprobamate.
Source: FDA drug label (Carisoprodol), Mylan Pharmaceuticals Inc., effective July 15, 2025 (SPL set 7c9184c0-7a2e-11df-8c8d-0002a5d5c51b), via openFDA; the full label on DailyMed
What does the omeprazole label say about carisoprodol?
Omeprazole's label (effective April 22, 2024) and its 1 other brand-application label do not name carisoprodol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carisoprodol | Omeprazole | |
|---|---|---|
| Labeled for | Muscle spasms and spasticity | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0706 per tablet 350 mg tablet | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once