Carisoprodol and Omeprazole Interaction
Drug interaction information between Carisoprodol and Omeprazole.
Carisoprodol and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carisoprodol and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole slows down the liver enzyme that breaks down carisoprodol, which can cause the drug to stay in your body longer.
FDA Label Information
Co-administration of CYP2C19 inhibitors, such as omeprazole or fluvoxamine, with carisoprodol could result in increased exposure of carisoprodol and decreased exposure of meprobamate.
Carisoprodol Also Interacts With
- Aspirin minor
- Rifampin minor
- Fluvoxamine minor
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Carisoprodol + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Carisoprodol's 4. In the minor band specifically: Carisoprodol has 4 (also Aspirin, Rifampin, Fluvoxamine); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Carisoprodol and Omeprazole?
Omeprazole slows down the liver enzyme that breaks down carisoprodol, which can cause the drug to stay in your body longer.
Omeprazole carries more major-labeled pairs than Carisoprodol
SPL source-record counts only. This page's band is minor · classes on file: Carisoprodol (Centrally Acting Muscle Relaxant); Omeprazole (Proton Pump Inhibitor (PPI)).
Omeprazole has 1 major-labeled pair vs Carisoprodol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Carisoprodol
- Aspirin
- Rifampin
- Fluvoxamine
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.