Atovaquone/Proguanil and Tetracycline Interaction
Drug interaction information between Atovaquone/Proguanil and Tetracycline.
Atovaquone/Proguanil and Tetracycline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atovaquone/Proguanil and Tetracycline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tetracycline can lower the amount of atovaquone in your body, making it harder for the drug to fight off the infection.
FDA Label Information
( 7.2 ) • Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. 7.3 Tetracycline Concomitant treatment with tetracycline has been associated with a reduction in plasma concentrations of atovaquone [see Clinical Pharmacology ( 12.3 )] . Parasitemia should be closely monitored in patients receiving tetracycline.
Atovaquone/Proguanil Also Interacts With
- Rifampin moderate
- Warfarin minor
- Metoclopramide minor
Tetracycline Also Interacts With
- Theophylline major
- Doxycycline moderate
- Doxycycline Hyclate moderate
- Minocycline moderate
- Zinc Sulfate minor
Frequently Asked Questions
What SPL severity band is on file for Atovaquone/Proguanil + Tetracycline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tetracycline has 12 labeled pairs on file vs Atovaquone/Proguanil's 4. In the minor band specifically: Atovaquone/Proguanil has 3 (also Warfarin, Metoclopramide); Tetracycline has 8 (also Zinc Sulfate, Cholestyramine, Colestipol, Dicloxacillin).
What mechanism field is on file for Atovaquone/Proguanil and Tetracycline?
Tetracycline can lower the amount of atovaquone in your body, making it harder for the drug to fight off the infection.
Tetracycline carries more major-labeled pairs than Atovaquone/Proguanil
SPL source-record counts only. This page's band is minor · classes on file: Atovaquone/Proguanil (Antimalarial Combination); Tetracycline (Tetracycline Antibiotic).
Tetracycline has 1 major-labeled pair vs Atovaquone/Proguanil's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 3 minor · 4 total
- Other minor peers for Atovaquone/Proguanil
- Warfarin
- Metoclopramide
1 major · 3 moderate · 8 minor · 12 total
- Other minor peers for Tetracycline
- Zinc Sulfate
- Cholestyramine
- Colestipol
- Dicloxacillin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.