Atovaquone/Proguanil and Metoclopramide Interaction
Drug interaction information between Atovaquone/Proguanil and Metoclopramide.
Atovaquone/Proguanil and Metoclopramide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atovaquone/Proguanil and Metoclopramide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide speeds up the digestive system, which can lower the total amount of atovaquone that gets into your blood.
FDA Label Information
7.4 Metoclopramide While antiemetics may be indicated for patients receiving MALARONE, metoclopramide may reduce the bioavailability of atovaquone and should be used only if other antiemetics are not available [see Clinical Pharmacology ( 12.3 )] .
Atovaquone/Proguanil Also Interacts With
- Rifampin moderate
- Warfarin minor
- Tetracycline minor
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Atovaquone/Proguanil + Metoclopramide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoclopramide has 23 labeled pairs on file vs Atovaquone/Proguanil's 4. In the minor band specifically: Atovaquone/Proguanil has 3 (also Warfarin, Tetracycline); Metoclopramide has 18 (also Acetaminophen, Cyclosporine, Tetracycline, Atropine).
What mechanism field is on file for Atovaquone/Proguanil and Metoclopramide?
Metoclopramide speeds up the digestive system, which can lower the total amount of atovaquone that gets into your blood.
Metoclopramide carries more major-labeled pairs than Atovaquone/Proguanil
SPL source-record counts only. This page's band is minor · classes on file: Atovaquone/Proguanil (Antimalarial Combination); Metoclopramide (Prokinetic / Antiemetic).
Metoclopramide has 1 major-labeled pair vs Atovaquone/Proguanil's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 3 minor · 4 total
- Other minor peers for Atovaquone/Proguanil
- Warfarin
- Tetracycline
1 major · 4 moderate · 18 minor · 23 total
- Other minor peers for Metoclopramide
- Acetaminophen
- Cyclosporine
- Tetracycline
- Atropine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.