What the FDA labels say about taking them together
Atovaquone/proguanil and rifampin
Atovaquone/proguanil's FDA label of June 10, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name atovaquone/proguanil. The atovaquone/proguanil label: “Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended.”
Check it at the source: the atovaquone/proguanil FDA label on DailyMed (effective June 10, 2026, GlaxoSmithKline LLC); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the atovaquone/proguanil label say about rifampin?
Atovaquone/proguanil label, drug interactionsAdministration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended.
Source: FDA drug label (MALARONE), GlaxoSmithKline LLC, effective June 10, 2026 (SPL set fc22e8d8-3bfb-4f70-a599-dd81262a4887), via openFDA; the full label on DailyMed
What does the rifampin label say about atovaquone/proguanil?
Rifampin's label (effective February 11, 2026) does not name atovaquone/proguanil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
These are the ingredient's own label sentences, repeated in a combination product's or a biosimilar's label. The ingredient pair sets them out with both labels side by side.
Both medicines on the record
| Atovaquone/proguanil | Rifampin | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.49 per tablet 250-100 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once