Atovaquone/Proguanil and Rifampin Interaction
Drug interaction information between Atovaquone/Proguanil and Rifampin.
Atovaquone/Proguanil and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Atovaquone/Proguanil and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin lowers the amount of atovaquone in your blood, which can make the medicine less effective at fighting infection.
FDA Label Information
7 DRUG INTERACTIONS • Administration with rifampin or rifabutin is known to reduce atovaquone concentrations; concomitant use with MALARONE is not recommended. ( 7.3 ) 7.1 Rifampin/Rifabutin Concomitant administration of rifampin or rifabutin is known to reduce atovaquone concentrations [see Clinical Pharmacology ( 12.3 )] . The concomitant administration of MALARONE and rifampin or rifabutin is not recommended.
Atovaquone/Proguanil Also Interacts With
- Warfarin minor
- Tetracycline minor
- Metoclopramide minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Atovaquone/Proguanil + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Atovaquone/Proguanil's 4. In the moderate band specifically: Atovaquone/Proguanil has 1; Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Atovaquone/Proguanil and Rifampin?
Rifampin lowers the amount of atovaquone in your blood, which can make the medicine less effective at fighting infection.
Rifampin carries more major-labeled pairs than Atovaquone/Proguanil
SPL source-record counts only. This page's band is moderate · classes on file: Atovaquone/Proguanil (Antimalarial Combination); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Atovaquone/Proguanil's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 3 minor · 4 total
Atovaquone/Proguanil has no other moderate-band peer in this dataset besides Rifampin.
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.