Tetracycline and Dicloxacillin Interaction
Drug interaction information between Tetracycline and Dicloxacillin.
Tetracycline and Dicloxacillin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tetracycline and Dicloxacillin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tetracycline stops bacteria from growing, which can prevent dicloxacillin from killing the bacteria effectively.
FDA Label Information
Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.
Tetracycline Also Interacts With
- Theophylline major
- Doxycycline moderate
- Doxycycline Hyclate moderate
- Minocycline moderate
- Zinc Sulfate minor
Dicloxacillin Also Interacts With
- Warfarin minor
- Probenecid minor
Frequently Asked Questions
What SPL severity band is on file for Tetracycline + Dicloxacillin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tetracycline has 12 labeled pairs on file vs Dicloxacillin's 3. In the minor band specifically: Tetracycline has 8 (also Zinc Sulfate, Atovaquone/Proguanil, Cholestyramine, Colestipol); Dicloxacillin has 3 (also Warfarin, Probenecid).
What mechanism field is on file for Tetracycline and Dicloxacillin?
Tetracycline stops bacteria from growing, which can prevent dicloxacillin from killing the bacteria effectively.
Tetracycline carries more major-labeled pairs than Dicloxacillin
SPL source-record counts only. This page's band is minor · classes on file: Tetracycline (Tetracycline Antibiotic); Dicloxacillin (Penicillinase-Resistant Penicillin).
Tetracycline has 1 major-labeled pair vs Dicloxacillin's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 8 minor · 12 total
- Other minor peers for Tetracycline
- Zinc Sulfate
- Atovaquone/Proguanil
- Cholestyramine
- Colestipol
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Dicloxacillin
- Warfarin
- Probenecid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.