Atovaquone/Proguanil and Warfarin Interaction
Drug interaction information between Atovaquone/Proguanil and Warfarin.
Atovaquone/Proguanil and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atovaquone/Proguanil and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Proguanil can increase the blood-thinning effects of warfarin, which may make you bleed more easily.
FDA Label Information
( 7.1 ) • Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. 7.2 Anticoagulants Proguanil may potentiate the anticoagulant effect of warfarin and other coumarin-based anticoagulants.
Atovaquone/Proguanil Also Interacts With
- Rifampin moderate
- Tetracycline minor
- Metoclopramide minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Atovaquone/Proguanil + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Atovaquone/Proguanil's 4. In the minor band specifically: Atovaquone/Proguanil has 3 (also Tetracycline, Metoclopramide); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Atovaquone/Proguanil and Warfarin?
Proguanil can increase the blood-thinning effects of warfarin, which may make you bleed more easily.
Warfarin carries more major-labeled pairs than Atovaquone/Proguanil
SPL source-record counts only. This page's band is minor · classes on file: Atovaquone/Proguanil (Antimalarial Combination); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Atovaquone/Proguanil's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 3 minor · 4 total
- Other minor peers for Atovaquone/Proguanil
- Tetracycline
- Metoclopramide
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.