aspirin vs fluoxetine
Side-by-side comparison of aspirin and fluoxetine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
NSAIDs, Aspirin, Warfarin): May potentiate the risk of bleeding ( 7.4 ) Drugs Tightly Bound to Plasma Proteins: May cause a shift in plasma concentrations ( 7.6 , 7.7 ) Olanzapine: When used in combination with fluoxetine, also refer to the Drug Interactions section of the package insert for Symbyax ( 7.7 ) Drugs that Prolong the QT Interval: Do not use fluoxetine with thioridazine or pimozide. 7.4 Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, Warfarin) Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and...
Recommendation: Your doctor should monitor you closely for any signs of unusual bleeding or bruising while taking these together.
Bayer, Ecotrin
Prozac, Sarafem
Aspirin is a common medicine used to relieve minor pain. It can also be prescribed by your doctor for other uses.
Fluoxetine is a medicine that can help treat depression and other mental health conditions. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Aspirin is used to temporarily relieve minor aches and pains. However, it works slowly. It will not quickly relieve headaches or other symptoms that need immediate relief. Ask your doctor about other uses for this medicine.
Fluoxetine can treat major depressive disorder in adults and children. It also treats obsessive-compulsive disorder (OCD) in adults and children. Fluoxetine can help with bulimia nervosa (an eating disorder) and panic disorder. Sometimes, it is used with another medicine called olanzapine to treat depression related to bipolar disorder.
Aspirin belongs to a class of drugs called NSAIDs and antiplatelets. It works by reducing substances in the body that cause pain and inflammation. It also helps to prevent blood clots.
Fluoxetine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluoxetine can help improve mood and reduce symptoms of depression, OCD, and other conditions.
- • Upset stomach
- • Heartburn
- • Abnormal dreams
- • Problems ejaculating
- • Loss of appetite
- • Feeling anxious
- • Feeling weak
- Tiredness 31,969
- Shortness of breath 27,184
- Feeling sick to your stomach 26,582
- Loose stools 26,451
- Feeling lightheaded 22,392
- The medicine is interacting with another medicine 3,336
- Harmful effect from different substances 3,316
- Feeling sick to your stomach 3,233
- Feeling tired 3,155
- Death by suicide 2,904
No specific warnings noted.
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior. Fluoxetine is not approved for use in children younger than 7 years old.
Ask your doctor for advice if you are pregnant or breastfeeding.
Talk to your doctor if you are pregnant or plan to become pregnant. Fluoxetine should only be used during pregnancy if the benefit outweighs the risk to the baby. Breastfeeding is not recommended while taking fluoxetine.
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How to Read This aspirin vs fluoxetine Comparison
aspirin is classified in the Antiplatelet / NSAID drug class, while fluoxetine sits within the Selective Serotonin Reuptake Inhibitor (SSRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aspirin has 134,578 submissions while fluoxetine has 15,944. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to both drugs can interfere with how your blood cells clump together to stop bleeding, which increases your risk of bruising or bleeding.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aspirin and fluoxetine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.