amphotericin B vs valganciclovir
Side-by-side comparison of amphotericin B and valganciclovir. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Cyclosporine or amphotericin B Unknown Monitor renal function when valganciclovir is coadministered with cyclosporine or amphotericin B because of potential increase in serum creatinine [see Warnings and Precautions (5.2)]. ( 7 ) Cyclosporine or amphotericin B: When coadministered with valganciclovir, the risk of nephrotoxicity may be increased.
Recommendation: Your doctor should check your kidney function frequently to ensure the organs are working properly during treatment.
Ambisome, Fungizone
Valcyte
Amphotericin B liposome is an antifungal medicine. It fights serious fungal infections in your body.
Valganciclovir is an antiviral medicine. It helps prevent cytomegalovirus (CMV) disease in children who have received kidney or heart transplants.
This medicine treats fungal infections like aspergillosis, candidiasis, and cryptococcosis. It can also treat cryptococcal meningitis in people with HIV. It may also be used for visceral leishmaniasis, but this infection can return, especially in those with weak immune systems.
This medicine prevents CMV disease in children after they get a kidney or heart transplant. CMV is a virus that can cause problems in people with weakened immune systems. Valganciclovir helps to stop the virus from growing and causing illness.
Amphotericin B liposome belongs to a class of drugs called polyene antifungals. It works by binding to the membrane of the fungal cells. This binding disrupts the fungal cell membrane, causing the cell to die.
Valganciclovir changes into ganciclovir in your body. Ganciclovir stops CMV from making copies of itself. This helps to prevent or treat CMV infections.
- • Abdominal pain
- • Weakness
- • Back pain
- • Chills
- • Pain
- • Diarrhea
- • Fever
- • Upper respiratory infection
- • Urinary tract infection
- • Vomiting
- Fever 974
- Condition got worse 842
- Fever with low white blood cell count 650
- Sudden kidney damage 625
- Blood infection 612
- CMV infection 1,756
- Low white blood cell count 1,096
- Fever 940
- Diarrhea 916
- Low white blood cell count 914
This medicine is not interchangeable with other amphotericin B products. Different versions of amphotericin B act differently in the body. Make sure you always get the correct medicine.
Valganciclovir can cause serious side effects, including: - Lowered blood cell counts. This can lead to infections and bleeding. - Fertility problems in both men and women. - Birth defects if taken during pregnancy. - Cancer. Talk to your doctor about these risks.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. Talk to your doctor about the risks and benefits of using this medicine during pregnancy or while breastfeeding.
This medicine can cause birth defects. Do not take it if you are pregnant or plan to become pregnant. Breastfeeding is not recommended while taking this medicine.
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How to Read This amphotericin B vs valganciclovir Comparison
amphotericin B is classified in the Polyene Antifungal drug class, while valganciclovir sits within the Antiviral (Nucleoside Analog) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amphotericin B has 3,703 submissions while valganciclovir has 5,622. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to both of these drugs can be hard on the kidneys, and using them at the same time increases the chance of kidney injury.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amphotericin B and valganciclovir - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.