Albendazole and Phenytoin Interaction
Drug interaction information between Albendazole and Phenytoin.
Albendazole and Phenytoin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Albendazole and Phenytoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Phenytoin causes your body to process albendazole faster, which reduces the amount of the active medicine available to fight infection.
FDA Label Information
Phenytoin when given with the combination of fosamprenavir and ritonavir may increase the concentration of amprenavir Calcium channel blockers Nifedipine, nimodipine, nisoldipine, verapamil Other Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine a The effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels is unpredictable 7.3 Drug/Laboratory Test Interactions Care should be taken when using immunoanalytical methods to measure serum phenytoin...
Albendazole Also Interacts With
- Theophylline minor
- Cimetidine minor
- Dexamethasone minor
- Carbamazepine minor
Phenytoin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Posaconazole major
- Ranolazine major
- Voriconazole major
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Albendazole + Phenytoin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenytoin has 147 labeled pairs on file vs Albendazole's 5. In the minor band specifically: Albendazole has 5 (also Theophylline, Cimetidine, Dexamethasone, Carbamazepine); Phenytoin has 120 (also Atorvastatin, Omeprazole, Simvastatin, Methylphenidate).
What mechanism field is on file for Albendazole and Phenytoin?
Phenytoin causes your body to process albendazole faster, which reduces the amount of the active medicine available to fight infection.
Phenytoin carries more major-labeled pairs than Albendazole
SPL source-record counts only. This page's band is minor · classes on file: Albendazole (Antiparasitic (Benzimidazole)); Phenytoin (Anticonvulsant (Hydantoin)).
Phenytoin has 4 major-labeled pairs vs Albendazole's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Albendazole
- Theophylline
- Cimetidine
- Dexamethasone
- Carbamazepine
4 major · 23 moderate · 120 minor · 147 total
- Other minor peers for Phenytoin
- Atorvastatin
- Omeprazole
- Simvastatin
- Methylphenidate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.