Albendazole and Cimetidine Interaction
Drug interaction information between Albendazole and Cimetidine.
Albendazole and Cimetidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Albendazole and Cimetidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine interferes with how the body breaks down albendazole, which causes the drug levels to rise in certain body fluids.
FDA Label Information
( 7.2 ) Cimetidine: Increased albendazole sulfoxide concentrations in bile and cystic fluid by about 2-fold in hydatid cyst patients. 7.3 Cimetidine Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n = 7) compared with albendazole (20 mg/kg/day) alone (n = 12).
Albendazole Also Interacts With
- Theophylline minor
- Dexamethasone minor
- Carbamazepine minor
- Phenytoin minor
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Albendazole + Cimetidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Albendazole's 5. In the minor band specifically: Albendazole has 5 (also Theophylline, Dexamethasone, Carbamazepine, Phenytoin); Cimetidine has 63 (also Alogliptin, Alosetron, Alprazolam, Amiodarone).
What mechanism field is on file for Albendazole and Cimetidine?
Cimetidine interferes with how the body breaks down albendazole, which causes the drug levels to rise in certain body fluids.
Cimetidine carries more major-labeled pairs than Albendazole
SPL source-record counts only. This page's band is minor · classes on file: Albendazole (Antiparasitic (Benzimidazole)); Cimetidine (H2 Receptor Antagonist).
Cimetidine has 4 major-labeled pairs vs Albendazole's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Albendazole
- Theophylline
- Dexamethasone
- Carbamazepine
- Phenytoin
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Alogliptin
- Alosetron
- Alprazolam
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.