Adenosine and Theophylline Interaction
Drug interaction information between Adenosine and Theophylline.
Adenosine and Theophylline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Adenosine and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Theophylline blocks the specific spots in your body where adenosine works, making the adenosine less effective.
FDA Label Information
Adenosine Theophylline blocks adenosine receptors. Higher doses of adenosine may be required to achieve desired effect. 25% increase Diazepam Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while theophylline blocks adenosine receptors.
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Adenosine + Theophylline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Adenosine's 2. In the minor band specifically: Adenosine has 2 (also Dipyridamole); Theophylline has 54 (also Propranolol, Methotrexate, Diazepam, Lithium).
What mechanism field is on file for Adenosine and Theophylline?
Theophylline blocks the specific spots in your body where adenosine works, making the adenosine less effective.
Theophylline carries more major-labeled pairs than Adenosine
SPL source-record counts only. This page's band is minor · classes on file: Adenosine (Endogenous Nucleoside (Antiarrhythmic)); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Adenosine's 0. This page itself is in the minor band, not the major band.
27 major · 5 moderate · 54 minor · 86 total
- Other minor peers for Theophylline
- Propranolol
- Methotrexate
- Diazepam
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.