Adenosine and Dipyridamole Interaction

Drug interaction information between Adenosine and Dipyridamole.

Adenosine and Dipyridamole have a documented minor interaction in FDA labeling.

FDA drug labeling documents a minor-severity interaction between Adenosine and Dipyridamole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Adenosine

Endogenous Nucleoside (Antiarrhythmic)

Drug B

Dipyridamole

Antiplatelet / Vasodilator

How They Interact

Dipyridamole causes adenosine levels to build up in the blood, which can make the effects on your heart and blood vessels stronger.

FDA Label Information

Adenosinergic agents (e.g., adenosine, regadenoson) Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be necessary. Dipyridamole also increases the cardiovascular effects of regadenoson, an adenosine A 2A -receptor agonist.

Adenosine Also Interacts With

View all Adenosine interactions →

Dipyridamole Also Interacts With

View all Dipyridamole interactions →

Frequently Asked Questions

What SPL severity band is on file for Adenosine + Dipyridamole?

Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Dipyridamole has 5 labeled pairs on file vs Adenosine's 2. In the minor band specifically: Adenosine has 2 (also Theophylline); Dipyridamole has 3 (also Enoxaparin, Nicardipine).

What mechanism field is on file for Adenosine and Dipyridamole?

Dipyridamole causes adenosine levels to build up in the blood, which can make the effects on your heart and blood vessels stronger.

Dipyridamole's labeled portfolio outnumbers Adenosine

SPL source-record counts only. This page's band is minor · classes on file: Adenosine (Endogenous Nucleoside (Antiarrhythmic)); Dipyridamole (Antiplatelet / Vasodilator).

Adenosine

0 major · 0 moderate · 2 minor · 2 total

Dipyridamole

0 major · 2 moderate · 3 minor · 5 total

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.