Acetaminophen/Oxycodone and Lamotrigine Interaction
Drug interaction information between Acetaminophen/Oxycodone and Lamotrigine.
Acetaminophen/Oxycodone and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acetaminophen/Oxycodone and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can lower the amount of lamotrigine in your blood, which may make the medicine less effective.
FDA Label Information
Lamotrigine Serum lamotrigine concentrations may be reduced, producing a decrease in therapeutic effects.
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Acetaminophen/Oxycodone + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lamotrigine has 24 labeled pairs on file vs Acetaminophen/Oxycodone's 23. In the minor band specifically: Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Cyclobenzaprine, Oxycodone); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Acetaminophen/Oxycodone and Lamotrigine?
This combination can lower the amount of lamotrigine in your blood, which may make the medicine less effective.
Lamotrigine's labeled portfolio outnumbers Acetaminophen/Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Acetaminophen/Oxycodone (Opioid Analgesic Combination); Lamotrigine (Anticonvulsant).
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Oxycodone
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.