What the FDA labels say about taking them together
Acetaminophen/oxycodone and lamotrigine
Acetaminophen/oxycodone's FDA label of December 23, 2025 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name acetaminophen/oxycodone. The acetaminophen/oxycodone label: “Lamotrigine Serum lamotrigine concentrations may be reduced, producing a decrease in therapeutic effects.”
Check it at the source: the acetaminophen/oxycodone FDA label on DailyMed (effective December 23, 2025, Aurolife Pharma, LLC); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the acetaminophen/oxycodone label say about lamotrigine?
Acetaminophen/oxycodone label, drug interactionsLamotrigine Serum lamotrigine concentrations may be reduced, producing a decrease in therapeutic effects.
Source: FDA drug label (Oxycodone and Acetaminophen), Aurolife Pharma, LLC, effective December 23, 2025 (SPL set 69df20d9-b1d5-47dc-9ff0-29987284f8c7), via openFDA; the full label on DailyMed
What does the lamotrigine label say about acetaminophen/oxycodone?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name acetaminophen/oxycodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen/oxycodone | Lamotrigine | |
|---|---|---|
| Labeled for | Pain | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.183 per tablet 7.5-325 mg tablet | $0.0268 per tablet 25 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once