What the FDA labels say about taking them together
Apomorphine and trimethobenzamide
Apomorphine's FDA label of February 24, 2022 names trimethobenzamide in its warnings and precautions section; the trimethobenzamide label PlainMeds reads does not name apomorphine. The apomorphine label: “The ability of concomitantly administered antiemetic drugs to reduce apomorphine-associated nausea/vomiting has not been studied.”
Check it at the source: the apomorphine FDA label on DailyMed (effective February 24, 2022, TruPharma, LLC); the trimethobenzamide FDA label on DailyMed (effective March 10, 2026, Par Health USA, LLC).
What does the apomorphine label say about trimethobenzamide?
Apomorphine label, warnings and precautionsThe effect of trimethobenzamide on reducing nausea and vomiting during treatment with apomorphine hydrocloride was evaluated in a 12-week, placebo-controlled study in 194 patients.
Onapgo label (MDD US Operations, LLC, a subsidiary of Supernus Pharmaceuticals, Inc, July 10, 2026), warnings and precautionsThe ability of concomitantly administered antiemetic drugs (other than trimethobenzamide) to reduce apomorphine-associated nausea/vomiting has not been studied.
Source: FDA drug label (Onapgo, NDA214056), MDD US Operations, LLC, a subsidiary of Supernus Pharmaceuticals, Inc, effective July 10, 2026 (SPL set f3552b6e-5ae7-4993-aa1a-e399c4a7080a), via openFDA
Source: FDA drug label (Apokyn, NDA021264), MDD US Operations, LLC, effective October 10, 2024 (SPL set 3235535d-9ef9-4657-8b2a-176a807d091c), via openFDA
Source: FDA drug label (apomorphine hydrocloride), ANDA212025 (Tp Anda Holdings), as published by TruPharma, LLC, effective February 24, 2022 (SPL set aedf70e4-1949-44bc-bf1b-0f282c4f0705), via openFDA; the full label on DailyMed
What does the trimethobenzamide label say about apomorphine?
Trimethobenzamide's label (effective March 10, 2026) does not name apomorphine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tigan), Par Health USA, LLC, effective March 10, 2026 (SPL set 7da90678-b229-4ad6-9193-2b8a3e9ba695), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apomorphine | Trimethobenzamide | |
|---|---|---|
| Labeled for | Parkinson's disease | Nausea and vomiting |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once